Can you take Apresoline with Bexagliflozin?
1 drug interaction and 12 additional warnings found for the following 2 drugs:
- Apresoline (hydralazine)
- bexagliflozin
Drug interactions
Moderate drug interactions
Moderate:
hydrALAZINE bexagliflozin
Applies to: Apresoline (hydralazine) and bexagliflozin
Bexagliflozin may cause salt and water loss, which may increase the risk of dehydration and low blood pressure when used with hydrALAZINE or similar medications. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Use caution when getting up from a sitting or lying position, and let your doctor know if you develop these symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Keep yourself hydrated by drinking plenty of fluids unless otherwise directed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
bexagliflozin Food/Lifestyle
Applies to: bexagliflozin
Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
hydrALAZINE Alcohol (Ethanol)
Applies to: Apresoline (hydralazine)
Ethanol and hydrALAZINE may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted. Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
10 potential interactions Applies to: 9 conditions, including Hypotension, Lupus Erythematosus, Liver Disease, Ischemic Heart Disease, and Valvular Heart Disease.
Bone Marrow Depression/Low Blood Counts
Major:
Apresoline
The hydrALAZINE in Apresoline has a major potential interaction with Bone Marrow Depression/Low Blood Counts.
Hydralazine may rarely cause blood dyscrasias at recommended dosages. Reduction in hemoglobin, red cell count, agranulocytosis, leukopenia, and purpura have been reported. Therapy with hydralazine should be administered cautiously in patients with these preexisting conditions and if such abnormalities develop during the course of therapy, treatment should be discontinued. Monitoring blood counts should be considered for those patients at higher risk.
Cerebral Vascular Disorder
Moderate:
Apresoline
The hydrALAZINE in Apresoline has a moderate potential interaction with Cerebral Vascular Disorder.
The vasodilatory effects of hydralazine may aggravate cerebral vasculopathy. Therapy with hydralazine should be administered cautiously in patients with cerebral vasculopathy.
Glomerulonephritis
Moderate:
Apresoline
The hydrALAZINE in Apresoline has a moderate potential interaction with Glomerulonephritis.
The use of hydralazine has been associated with the development of glomerulonephritis. Hydralazine should be used with caution in patients with advanced renal damage and these patients may require a lower dose. Renal function should be monitored and supported as required.
Hypotension
Moderate:
bexagliflozin
Bexagliflozin has a moderate potential interaction with Hypotension.
Bexagliflozin can cause intravascular volume contraction which may sometimes manifest as symptomatic hypotension or acute transient changes in creatinine. There have been postmarketing reports of acute kidney injury, some requiring hospitalization and dialysis, in patients with type 2 diabetes mellitus receiving SGLT2 inhibitors. Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m2), elderly patients, patients with low systolic blood pressure, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. Before initiating bexagliflozin in patients with one or more of these characteristics, assess volume status and renal function. In patients with volume depletion, correct this condition before treatment initiation.
Ischemic Heart Disease
Major:
Apresoline
The hydrALAZINE in Apresoline has a major potential interaction with Ischemic Heart Disease.
The use of hydralazine is contraindicated in patients with coronary artery disease. Reflex tachycardia may commonly occur. Palpitations and chest pain have also been reported. Myocardial infarction has been associated with the use of hydralazine.
Liver Disease
Moderate:
bexagliflozin
Bexagliflozin has a moderate potential interaction with Liver Disease.
Bexagliflozin has not been studied in patients with severe hepatic impairment and is not recommended for use in this patient population. The recommended dosage for patients with mild to moderate hepatic impairment is the
same as the recommended dosage for patients with normal hepatic function.
Lupus Erythematosus
Major:
Apresoline
The hydrALAZINE in Apresoline has a major potential interaction with Lupus Erythematosus.
The use of hydralazine has been associated with the development of lupus erythematosus and lupus-like syndromes, as well as exacerbation of the disease. Hydralazine therapy should be withdrawn in patients experiencing worsening of preexisting lupus. Monitoring complete blood counts, and antinuclear antibody titers before and during prolonged therapy is recommended.
Renal Dysfunction
Major:
bexagliflozin
Bexagliflozin has a major potential interaction with Renal Dysfunction.
Bexagliflozin is contraindicated in patients on dialysis, and is not recommended in patients with an eGFR less than 30 mL/min/1.73 m2 due to the decline of the glucose lowering effect of this drug and reduction in
urine output in these patients.
Moderate:
Apresoline
The hydrALAZINE in Apresoline has a moderate potential interaction with Renal Dysfunction.
The use of hydralazine has been associated with the development of glomerulonephritis. Hydralazine should be used with caution in patients with advanced renal damage and these patients may require a lower dose. Renal function should be monitored and supported as required.
Valvular Heart Disease
Major:
Apresoline
The hydrALAZINE in Apresoline has a major potential interaction with Valvular Heart Disease.
The use of hydralazine is contraindicated in patients with mitral valvular rheumatic heart disease.
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More resources
Apresoline
A total of 440 drugs are known to interact with Apresoline.
- Apresoline is in the drug class vasodilators.
- Apresoline is used to treat the following conditions:
bexagliflozin
A total of 419 drugs are known to interact with bexagliflozin.
- Bexagliflozin is in the drug class SGLT-2 inhibitors.
- Bexagliflozin is used to treat Type 2 Diabetes.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.