Zurnai Dosage
Generic name: NALMEFENE HYDROCHLORIDE 1.5mg in 0.50mL
Dosage form: injection, solution
Drug class: Antidotes
Medically reviewed by Drugs.com. Last updated on Jun 6, 2025.
Important Administration Instructions
- All approved nalmefene products achieve plasma concentrations that have been shown to be efficacious in reversing the effects of opioid overdose. Comparing different products on a nominal mg-for-mg basis may be misleading.
- ZURNAI is for intramuscular and subcutaneous use only.
- The device is ready to use. No device assembly is required.
- Do not prime or test prior to administration. ZURNAI delivers its entire contents automatically, upon injection.
- Inject ZURNAI into the anterolateral aspect of the thigh.
- ZURNAI can be administered through clothing if necessary.
- Do not reuse ZURNAI. Each ZURNAI device contains a single dose of nalmefene and cannot be reused.
- Because treatment of suspected opioid overdose must be performed by someone other than the patient, instruct the prescription recipient to inform those around them about the presence of ZURNAI and the Instructions for Use.
- Instruct the patient or caregiver to read the Instructions for Use at the time they receive a prescription for ZURNAI. Emphasize the following instructions to the patient or caregiver:
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- Administer ZURNAI as quickly as possible because prolonged respiratory depression may result in damage to the central nervous system or death.
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- Always seek emergency medical assistance after administration of the first dose of ZURNAI in the event of a suspected, potentially life-threatening opioid emergency. Keep the patient under continued surveillance until emergency personnel arrive.
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- Additional doses of ZURNAI may be required until emergency medical assistance becomes available.
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- If available, re-administer ZURNAI using a new auto-injector, every 2 to 5 minutes if the patient does not respond or responds and then relapses into respiratory depression.
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- Once the safety seal is broken and blue cap is removed, ZURNAI must be used immediately or disposed of properly. Do not attempt to replace the blue cap once it is removed.
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- Visually inspect ZURNAI through the viewing window for particulate matter and discoloration prior to administration. Do not administer unless the solution is clear, free of particulates, and the glass container is undamaged.
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- Administer ZURNAI according to the printed instructions on the device label, carton, and the Instructions for Use.
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- Place the needle guard of ZURNAI against the outer thigh. Press the needle end firmly into the injection site until you hear a click and then hold for 3 seconds. After 3 seconds, the viewing window should turn completely orange, signaling that ZURNAI has delivered the intended dose of nalmefene.
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- Remove ZURNAI from the outer thigh.
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- Call for emergency medical assistance immediately after administration of the first dose of ZURNAI.
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- Move the patient on their side (recovery position). Remain with the patient until emergency medical assistance arrives, even if the patient wakes up.
Dosing in Adults and Pediatric Patients 12 Years and Older
Initial Dosing:
The recommended dose of ZURNAI in adults and pediatric patients aged 12 years and older is 1.5 mg delivered by intramuscular or subcutaneous injection into the anterolateral aspect of the thigh, through clothing if necessary.
Repeat Dosing:
Seek emergency medical assistance as soon as possible after administration of the first dose of ZURNAI. The requirement for repeat doses of ZURNAI depends upon the amount, type, and route of administration of the opioid being antagonized.
If the patient responds to ZURNAI and subsequently relapses back into respiratory depression before emergency assistance arrives, administer an additional dose of ZURNAI using a new auto-injector and continue surveillance of the patient.
If the desired response is not obtained after 2 to 5 minutes, administer an additional dose of ZURNAI using a new auto-injector. If there is still no response and additional doses are available, administer additional doses of ZURNAI every 2 to 5 minutes using a new ZURNAI auto-injector for each dose until emergency medical assistance arrives.
Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.
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