Skip to Content

Vasostrict Dosage

Medically reviewed by Drugs.com. Last updated on Mar 26, 2021.

Generic name: VASOPRESSIN, UNSPECIFIED 20[USP'U] in 1mL
Dosage form: injection

Preparation of Solution

Inspect parenteral drug products for particulate matter and discoloration prior to use, whenever solution and container permit.

Vasostrict® Solution for Dilution, 20 units/mL and 200 units/10 mL (20 units/mL)

Dilute Vasostrict® in normal saline (0.9% sodium chloride) or 5% dextrose in water (D5W) prior to use for intravenous administration. Discard unused diluted solution after 18 hours at room temperature or 24 hours under refrigeration.

Table 1 Preparation of diluted solutions
Fluid restriction? Final concentration Mix
Vasostrict® Diluent

No

0.1 units/mL

2.5 mL (50 units)

500 mL

Yes

1 unit/mL

5 mL (100 units)

100 mL

Vasostrict® Premixed Solution, 40 units/100 mL (0.4 units/mL) and 60 units/100 mL (0.6 units/mL)

This product does not require further dilution prior to administration.

Administration

In general, titrate to the lowest dose compatible with a clinically acceptable response.

The recommended starting dose is:

Post-cardiotomy shock: 0.03 units/minute

Septic Shock: 0.01 units/minute

Titrate up by 0.005 units/minute at 10- to 15-minute intervals until the target blood pressure is reached. There are limited data for doses above 0.1 units/minute for post-cardiotomy shock and 0.07 units/minute for septic shock. Adverse reactions are expected to increase with higher doses.

After target blood pressure has been maintained for 8 hours without the use of catecholamines, taper vasopressin injection by 0.005 units/minute every hour as tolerated to maintain target blood pressure.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.