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Ublituximab Dosage

Medically reviewed by Last updated on Apr 18, 2023.

Applies to the following strengths: xiiy 150 mg/6 mL

Usual Adult Dose for Multiple Sclerosis

First Infusion:
150 mg IV over at least 4 hours

Second Infusion (2 weeks after the first infusion):
450 mg IV over at least 1 hour

Subsequent Infusions (24 weeks after the first infusion):
450 mg IV every 24 weeks over at least 1 hour


Use: For the treatment of relapsing forms of multiple sclerosis in adults

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Dose adjustment may be required; however, no specific guidelines have been suggested.

Dose Adjustments

Refer to manufacturer product information for full details on dose modification and management of adverse reactions.

Life-Threatening Infusion Reactions:

Severe Infusion Reactions:

Mild to Moderate Infusion Reactions:


Active HBV infection; life-threatening infusion reaction

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:

Diluted solution:

Preparation techniques:
Use 0.9% Sodium Chloride Injection, USP to dilute this drug.

Preparation of Solution for First Infusion:

Preparation of Solution for Second Infusion and Subsequent Infusions:

IV compatibility: No incompatibilities were observed between this drug and polyvinyl chloride (PVC) or polyolefin (PO) bags or intravenous (IV) administration sets.



Patient advice:
­Contact your health care provider immediately if you have signs or symptoms of infusion reactions during treatment or after the last infusion. Signs may include fever, chills, a constant cough, or dysuria.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.