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Tybost Dosage

Generic name: COBICISTAT 150mg
Dosage form: tablet, film coated

Medically reviewed on August 1, 2018.

Recommended Dosage

Administer TYBOST in conjunction with atazanavir or darunavir and other antiretroviral agents in the treatment of adults with HIV-1 infection. The recommended dosages of TYBOST and atazanavir or darunavir given with food are presented in Table 1. TYBOST must be coadministered at the same time as atazanavir or darunavir [see Drug Interactions (7)]. Consult the prescribing information for atazanavir or darunavir.

Table 1 Recommended Dosing Regimens
TYBOST Dosage Coadministered Agent Dosage Patient Populations
150 mg orally once daily atazanavir 300 mg orally once daily Treatment-naïve or experienced
darunavir 800 mg orally once daily Treatment-naïve
Treatment-experienced with no darunavir resistance associated substitutions

Testing Prior to Initiation of TYBOST

Prior to starting TYBOST, assess estimated creatinine clearance because TYBOST decreases estimated creatinine clearance due to inhibition of tubular secretion of creatinine without affecting actual renal glomerular function [see Warnings and Precautions (5.1)]. When coadministering TYBOST with tenofovir disoproxil fumarate (tenofovir DF), assess estimated creatinine clearance, urine glucose, and urine protein at baseline [see Warnings and Precautions 5.2].

Renal Impairment

TYBOST coadministered with tenofovir DF is not recommended in patients who have an estimated creatinine clearance below 70 mL/min because dose adjustment of tenofovir DF is required below 50 mL/min and such dose adjustments have not been established for coadministration with TYBOST [see Warnings and Precautions (5.2) and Adverse Reactions (6.1)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.