Tetanus Immune Globulin Dosage

Usual Adult Dose for Tetanus

Routine prophylaxis:
250 units (1 syringe) deep intramuscularly

• At the same time, in a different extremity with a different syringe, administer Tetanus and Diphtheria Toxoids Adsorbed (Td)

Treatment of active cases: Dose adjusted to severity of infection

• Start treatment immediately

Comments:

• For use in patients with wounds that are not clean and minor AND who have had less than 3 doses of tetanus immunization (or immunization history is unknown).
• Appropriate wounds include, but are not limited to, those contaminated with dirt, feces, soil, or saliva; puncture wounds; avulsions; and wounds from missiles, crushing, burns, and frostbite.
• Make thorough attempt to determine the patients vaccination status; unknown or uncertain histories should be considered to have no vaccination.
• Patients with military service since 1941 can be considered to have 1 dose of vaccination; although most completed the series, this cannot be assumed.
• Unvaccinated patients may require vaccination and passive immunization at the time of wound cleaning and debridement.
• Patients should continue to receive the full vaccination series.
• If contraindications to primary tetanus vaccination exist, only this drug/passive immunization should be given.

Usual Adult Dose for Tetanus Prophylaxis

Routine prophylaxis:
250 units (1 syringe) deep intramuscularly

• At the same time, in a different extremity with a different syringe, administer Tetanus and Diphtheria Toxoids Adsorbed (Td)

Treatment of active cases: Dose adjusted to severity of infection

• Start treatment immediately

Comments:

• For use in patients with wounds that are not clean and minor AND who have had less than 3 doses of tetanus immunization (or immunization history is unknown).
• Appropriate wounds include, but are not limited to, those contaminated with dirt, feces, soil, or saliva; puncture wounds; avulsions; and wounds from missiles, crushing, burns, and frostbite.
• Make thorough attempt to determine the patients vaccination status; unknown or uncertain histories should be considered to have no vaccination.
• Patients with military service since 1941 can be considered to have 1 dose of vaccination; although most completed the series, this cannot be assumed.
• Unvaccinated patients may require vaccination and passive immunization at the time of wound cleaning and debridement.
• Patients should continue to receive the full vaccination series.
• If contraindications to primary tetanus vaccination exist, only this drug/passive immunization should be given.

Usual Pediatric Dose for Tetanus

Routine prophylaxis:
7 years and older: 250 units (1 syringe) deep intramuscularly

• At the same time, in a different extremity with a different syringe, administer Tetanus and Diphtheria Toxoids Adsorbed (Td)

Under 7 years: Dose may be calculated at 4 units/kg, however use of the entire 250 unit syringe may be advisable regardless of the child's size, as the infection will produce the same amount of toxin as will be produced in adults.

Treatment of active cases: Dose adjusted to severity of infection

• Start treatment immediately

Comments:

• For use in patients with wounds that are not clean and minor AND who have had less than 3 doses of tetanus immunization (or immunization history is unknown).
• Appropriate wounds include, but are not limited to, those contaminated with dirt, feces, soil, or saliva; puncture wounds; avulsions; and wounds from missiles, crushing, burns, and frostbite.
• Make thorough attempt to determine the patients vaccination status; unknown or uncertain histories should be considered to have no vaccination.
• Patients with military service since 1941 can be considered to have 1 dose of vaccination; although most completed the series, this cannot be assumed.
• Unvaccinated patients may require vaccination and passive immunization at the time of wound cleaning and debridement.
• Patients should continue to receive the full vaccination series.
• If contraindications to primary tetanus vaccination exist, only this drug/passive immunization should be given.

Usual Pediatric Dose for Tetanus Prophylaxis

Routine prophylaxis:
7 years and older: 250 units (1 syringe) deep intramuscularly

• At the same time, in a different extremity with a different syringe, administer Tetanus and Diphtheria Toxoids Adsorbed (Td)

Under 7 years: Dose may be calculated at 4 units/kg, however use of the entire 250 unit syringe may be advisable regardless of the child's size, as the infection will produce the same amount of toxin as will be produced in adults.

Treatment of active cases: Dose adjusted to severity of infection

• Start treatment immediately

Comments:

• For use in patients with wounds that are not clean and minor AND who have had less than 3 doses of tetanus immunization (or immunization history is unknown).
• Appropriate wounds include, but are not limited to, those contaminated with dirt, feces, soil, or saliva; puncture wounds; avulsions; and wounds from missiles, crushing, burns, and frostbite.
• Make thorough attempt to determine the patients vaccination status; unknown or uncertain histories should be considered to have no vaccination.
• Patients with military service since 1941 can be considered to have 1 dose of vaccination; although most completed the series, this cannot be assumed.
• Unvaccinated patients may require vaccination and passive immunization at the time of wound cleaning and debridement.
• Patients should continue to receive the full vaccination series.
• If contraindications to primary tetanus vaccination exist, only this drug/passive immunization should be given.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None known

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For intramuscular (IM) use only; do not give intravenously (IV).
• Use care to pull back on the syringe before IM injections to ensure the needle is not in a blood vessel.
• The deltoid of the upper arm or lateral thigh are preferred IM injection sites; do not use the gluteal region as sciatic nerve damage may occur.

Storage requirements:

• Refrigerate; do not freeze
• Do not use if product has been frozen

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer