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Targretin Dosage

Generic name: BEXAROTENE 75mg
Dosage form: capsule, liquid filled
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com. Last updated on Apr 22, 2024.

The recommended initial dose of TARGRETIN is 300 mg/m2/day (see Table 1). TARGRETIN should be taken as a single oral daily dose with a meal. For precautions to prevent pregnancy and birth defects in women of child-bearing potential [see Use in Specific Populations (8.1)].

Table 1: TARGRETIN Initial Dose Calculation According to Body Surface Area

Initial Dose Level (300 mg/m2/day)

Number of 75 mg
TARGRETIN Capsules

Body Surface Area

(m2)

Total Daily Dose

(mg/day)

0.88 – 1.12

300

4

1.13 – 1.37

375

5

1.38 – 1.62

450

6

1.63 – 1.87

525

7

1.88 – 2.12

600

8

2.13 – 2.37

675

9

2.38 – 2.62

750

10

Dose Modification Guidelines: The 300 mg/m2/day dose level of TARGRETIN may be adjusted to 200 mg/m2/day then to 100 mg/m2/day, or temporarily suspended, if necessitated by toxicity. When toxicity is controlled, doses may be carefully readjusted upward. If there is no tumor response after 8 weeks of treatment and if the initial dose of 300 mg/m2/day is well tolerated, the dose may be escalated to 400 mg/m2/day with careful monitoring.

Duration of Therapy: In clinical trials in CTCL, TARGRETIN was administered for up to 97 weeks.

TARGRETIN should be continued as long as the patient is deriving benefit.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.