Targretin Dosage

Generic name: BEXAROTENE 75mg
Dosage form: capsule, liquid filled
Drug class: Miscellaneous antineoplastics

Medically reviewed by Drugs.com. Last updated on Apr 21, 2025.

The recommended initial dose of TARGRETIN is 300 mg/m2/day (see Table 1). TARGRETIN should be taken as a single oral daily dose with a meal. For precautions to prevent pregnancy and birth defects in women of child-bearing potential.

Table 1: TARGRETIN Initial Dose Calculation According to Body Surface Area
Initial Dose Level (300 mg/m2/day)		Number of 75 mg TARGRETIN Capsules
Body Surface Area (m2)	Total Daily Dose (mg/day)	Number of 75 mg TARGRETIN Capsules
0.88 – 1.12	300	4
1.13 – 1.37	375	5
1.38 – 1.62	450	6
1.63 – 1.87	525	7
1.88 – 2.12	600	8
2.13 – 2.37	675	9
2.38 – 2.62	750	10

Dose Modification Guidelines: The 300 mg/m2/day dose level of TARGRETIN may be adjusted to 200 mg/m2/day then to 100 mg/m2/day, or temporarily suspended, if necessitated by toxicity. When toxicity is controlled, doses may be carefully readjusted upward. If there is no tumor response after 8 weeks of treatment and if the initial dose of 300 mg/m2/day is well tolerated, the dose may be escalated to 400 mg/m2/day with careful monitoring.

Duration of Therapy: In clinical trials in CTCL, TARGRETIN was administered for up to 97 weeks.

TARGRETIN should be continued as long as the patient is deriving benefit.