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Protein C Dosage

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Protein C Deficiency

Acute episode or short-term prophylaxis:
Initial dose: 100 to 120 international units/kg intravenously
Subsequent doses: 60 to 80 international units/kg every 6 hours
Maintenance dose: 45 to 60 international units/kg every 6 or 12 hours

Long-term prophylaxis: 45 to 60 international units/kg every 12 hours

Comments:
-Adjust dose to maintain target protein C activity of 100%
-After resolution of an acute episode, maintain trough protein C level above 25% for the duration of treatment.
-During prophylactic use, higher peak protein C levels may be warranted if thrombosis risk is increased (e.g. infection, trauma, surgical intervention); maintaining trough protein C levels over 25% is recommended.
-Adjust the dose according to the individual patient pharmacokinetic profile.

Use: Prevention and treatment of venous thrombosis and purpura fulminans in patients with severe congenital protein C deficiency.

Usual Pediatric Dose for Protein C Deficiency

Acute episode or short-term prophylaxis:
Initial dose: 100 to 120 international units/kg intravenously
Subsequent doses: 60 to 80 international units/kg every 6 hours
Maintenance dose: 45 to 60 international units/kg every 6 or 12 hours

Long-term prophylaxis: 45 to 60 international units/kg every 12 hours

Comments:
-Adjust dose to maintain target protein C activity of 100%
-After resolution of an acute episode, maintain trough protein C level above 25% for the duration of treatment.
-During prophylactic use, higher peak protein C levels may be warranted if thrombosis risk is increased (e.g. infection, trauma, surgical intervention); maintaining trough protein C levels over 25% is recommended.
-Adjust the dose according to the individual patient pharmacokinetic profile.

Use: Prevention and treatment of venous thrombosis and purpura fulminans in patients with severe congenital protein C deficiency.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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