Pentoxifylline Dosage

Medically reviewed by Drugs.com. Last updated on Aug 3, 2023.

Applies to the following strengths: 400 mg

Usual Adult Dose for:

Intermittent Claudication

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Intermittent Claudication

400 mg orally 3 times a day. If adverse effects develop, reducing the dose to 400 mg twice a day is recommended.

Renal Dose Adjustments

Creatine Clearance 10 to 50 mL/min:
400 mg orally twice a day. If adverse effects develop, reducing the dose to 400 mg once a day is recommended.
Creatine Clearance less than 10 mL/min:
400 mg orally once a day. Further dosage reduction may be required such as 200 mg once daily but current products (extended or controlled release; unscored) may require adaptation to 400 mg once every other day.

Note: Pentoxifylline is not eliminated unchanged in the urine; however, the pharmacologically active metabolite may accumulate in patients with renal impairment and add to pharmacologic and toxic effects.

Liver Dose Adjustments

400 mg orally twice a day. If adverse effects develop, reducing the dose to 400 mg once a day is recommended.

Dose Adjustments

In patients with both renal and liver dysfunction, the dose should be reduced to 400 mg orally once a day.

Precautions

Patients with impaired renal and/or liver function should be monitored closely for adverse effects.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Limited data suggest that pentoxifylline is moderately dialyzed during hemodialysis. Therefore, doses should follow hemodialysis sessions.

Other Comments

Pentoxifylline is preferably given with meals to decrease gastric irritation. Pentoxifylline should be given for at least 8 weeks to determine efficacy.