Pegcetacoplan Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Oct 23, 2023.

Usual Adult Dose for Macular Degeneration

15 mg (0.1 mL of 150 mg/mL solution) intravitreal injection to each affected eye once every 25 to 60 days

Comments:

• Monitor the patient for elevated intraocular pressure (IOP) using tonometry before and after the intravitreal injection; if needed, ocular hypotensive medication can be given to lower the IOP.
• Administer adequate anesthesia and a broad-spectrum topical microbicide to disinfect the periocular skin, eyelid, and ocular surface prior to the injection.
• Do not use the filter needle for injection.
• Each vial should only be used for the treatment of a single eye.

Use: For the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: Ocular or periocular infections; active intraocular inflammation

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug must be administered by a trained physician.
• Store the vial at room temperature for at least 15 minutes prior to injection but no longer than 8 hours.
• Administer injection under aseptic conditions using surgical hand disinfection, sterile gloves, a sterile drape, and a sterile eyelid speculum (or equivalent) immediately after the dose preparation.
• Do not use the filter needle for injection.
• Do not use if:
• particulates, cloudiness, or discoloration are visible.
• the vial shows signs of damage or tampering.
• if the expiration date has passed.

Storage requirements:

• Refrigerate between 2C to 8C (36F to 46F). Store the vial in the original carton to protect from light.
• Do not use beyond the expiration date.
• Do not shake the vial.

Reconstitution/preparation technique:

• The manufacturer product information should be consulted.

Patient advice:

• Neovascular AMD, endophthalmitis, and retinal detachments may develop with the use of this drug.
• Seek immediate care from an ophthalmologist if the eye becomes red, sensitive to light, painful, or change in vision such as flashing lights, blurred vision, or metamorphopsia occurs.
• Temporary visual disturbances might be experienced; do not drive or use machinery until visual function has sufficiently recovered.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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