Pegcetacoplan Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Oct 23, 2023.

Usual Adult Dose for Macular Degeneration

15 mg (0.1 mL of 150 mg/mL solution) intravitreal injection to each affected eye once every 25 to 60 days

Comments:

• Monitor the patient for elevated intraocular pressure (IOP) using tonometry before and after the intravitreal injection; if needed, ocular hypotensive medication can be given to lower the IOP.
• Administer adequate anesthesia and a broad-spectrum topical microbicide to disinfect the periocular skin, eyelid, and ocular surface prior to the injection.
• Do not use the filter needle for injection.
• Each vial should only be used for the treatment of a single eye.

Use: For the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: Ocular or periocular infections; active intraocular inflammation

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug must be administered by a trained physician.
• Store the vial at room temperature for at least 15 minutes prior to injection but no longer than 8 hours.
• Administer injection under aseptic conditions using surgical hand disinfection, sterile gloves, a sterile drape, and a sterile eyelid speculum (or equivalent) immediately after the dose preparation.
• Do not use the filter needle for injection.
• Do not use if:
• particulates, cloudiness, or discoloration are visible.
• the vial shows signs of damage or tampering.
• if the expiration date has passed.

Storage requirements:

• Refrigerate between 2C to 8C (36F to 46F). Store the vial in the original carton to protect from light.
• Do not use beyond the expiration date.
• Do not shake the vial.

Reconstitution/preparation technique:

• The manufacturer product information should be consulted.

Patient advice:

• Neovascular AMD, endophthalmitis, and retinal detachments may develop with the use of this drug.
• Seek immediate care from an ophthalmologist if the eye becomes red, sensitive to light, painful, or change in vision such as flashing lights, blurred vision, or metamorphopsia occurs.
• Temporary visual disturbances might be experienced; do not drive or use machinery until visual function has sufficiently recovered.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer