Opvee Nasal Spray Dosage
Generic name: NALMEFENE HYDROCHLORIDE 2.7mg in 100uL
Dosage form: nasal spray
Drug class: Antidotes
Medically reviewed by Drugs.com. Last updated on Nov 11, 2024.
Important Administration Instructions
- OPVEE is for intranasal use only.
- The device is ready to use. No device assembly is required.
- Do not prime or test prior to administration. OPVEE nasal spray delivers its entire contents automatically, upon activation.
- Do not attempt to reuse OPVEE. Each unit-dose device contains a single dose of nalmefene and cannot be reused.
- No device assembly is required.
- Because treatment of suspected opioid overdose must be performed by someone other than the patient, instruct the prescription recipient to inform those around them about the presence of OPVEE nasal spray and the Instructions for Use.
- Instruct the patient or caregiver to read the Instructions for Useat the time they receive a prescription for OPVEE nasal spray. Emphasize the following instructions to the patient or caregiver:
- Administer OPVEE nasal spray as quickly as possiblebecause prolonged respiratory depression may result in damage to the central nervous system or death.
- Always seek emergency medical assistance after administration of the first dose of OPVEE nasal spray in the event of a suspected, potentially life-threatening opioid emergency. Keep the patient under continued surveillance until emergency personnel arrive.
- Additional doses of OPVEE nasal spray may be required until emergency medical assistance becomes available.
- Re-administer OPVEE nasal spray, using a new nasal spray, in the nose, every 2 to 5 minutes if the patient does not respond or responds and then relapses into respiratory depression.
- Administer OPVEE nasal spray according to the printed instructions on the Quick Start Guideand the Instructions for Use.
- Place the patient in the supine position. Prior to administration, be sure the device nozzle is inserted in the nose of the patient and provide support to the back of the neck to allow the head to tilt back. Do not prime or test the device prior to administration.
- To administer the dose, press firmly on the device plunger and remove the device nozzle from the nose after use.
- If the patient responds by waking up to the voice or touch or starts breathing normally, place the patient on their side (recovery position) as shown in the Instructions for Useand call for emergency medical assistance immediately after administration of the first dose of OPVEE nasal spray.
Dosing in Adults and Pediatric Patients aged 12 years and older
Initial Dosing:
The recommended initial dose of OPVEE nasal spray in adults and pediatric patients aged 12 years and older is one spray delivered by intranasal administration, which delivers 2.7 mg of nalmefene.
Repeat Dosing:
Seek emergency medical assistance as soon as possible after intranasal administration of the first dose of OPVEE nasal spray. The requirement for repeat doses of OPVEE nasal spray (2.7 mg) depends upon the amount, type, and route of administration of the opioid being antagonized.
If the patient responds to OPVEE nasal spray and relapses back into respiratory depression before emergency assistance arrives, administer an additional dose of OPVEE in the opposite nostril using a new OPVEE nasal spray and continue surveillance of the patient.
If the desired response is not obtained after 2 to 5 minutes, administer an additional dose of OPVEE using a new OPVEE nasal spray device. If there is still no response and additional doses are available, administer additional doses of OPVEE nasal spray every 2 to 5 minutes using a new OPVEE nasal spray device with each dose until emergency medical assistance arrives.
Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.
Dosing Modifications due to Partial Agonists or Mixed Agonists/Antagonists
Reversal of respiratory depression by partial agonists or mixed agonist/antagonists, such as buprenorphine and pentazocine, may be incomplete and require repeated administration of OPVEE nasal spray using a new nasal spray device .
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