Generic name: NITRIC OXIDE 800mg in 1L
Dosage form: gas
Drug class: Miscellaneous respiratory agents
Medically reviewed by Drugs.com. Last updated on Jan 19, 2023.
The recommended dose is 20 ppm, maintained for up to 14 days or until the underlying oxygen desaturation has resolved ( 2.1).
Doses greater than 20 ppm are not recommended ( 2.1, 5.2) Administration:
• Use only with a NOxBOXi® operated by trained personnel ( 2.2)
• Avoid abrupt discontinuation ( 2.2, 5.1).
Term and near-term neonates with hypoxic respiratory failure
The recommended dose of Noxivent™ is 20 ppm. Maintain treatment up to 14 days or until the underlying oxygen desaturation has resolved and the neonate is ready to be weaned from Noxivent™ therapy. Doses greater than 20 ppm are not recommended [see Warnings and Precautions (5.2)].
Training in Administration
The user of Noxivent™ and Nitric Oxide Delivery Systems must satisfactorily complete a comprehensive periodic training program for health care professionals provided by the delivery system and drug manufacturers. Health professional staff that administers nitric oxide therapy have access to supplier-provided 24 hour/365 days per year technical support on the delivery and administration of Noxivent™ at 1-833-669-8368.
Nitric Oxide Delivery Systems
Noxivent™ must be administered using a calibrated NOxBOXi®. Only validated ventilator systems should be used in conjunction with Noxivent™. Consult the Nitric Oxide Delivery System label or call 833-669-8368/visit linde.com for a current list of validated systems. Keep available a backup battery power supply and an independent reserve nitric oxide delivery system to address power and system failures.
Measure methemoglobin within 4-8 hours after initiation of treatment with Noxivent™ and periodically throughout treatment [see Warnings and Precautions (5.2)]. Monitor for PaO 2 and inspired NO 2 during Noxivent™ administration [see Warnings and Precautions 5.3)].
Weaning and Discontinuation
Avoid abrupt discontinuation of Noxivent™ [see Warnings and Precautions (5.1)]. To wean Noxivent™, downtitrate in several steps, pausing several hours at each step to monitor for hypoxemia.
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