Medically reviewed by Drugs.com. Last updated on Dec 6, 2021.
Generic name: NITRIC OXIDE 800mg in 1L
Dosage form: gas
The recommended dose is 20 ppm, maintained for up to 14 days or until the underlying oxygen desaturation has resolved (2.1).
Term and near-term neonates with hypoxic respiratory failure
The recommended dose of Noxivent™ is 20 ppm. Maintain treatment up to 14 days or until the underlying oxygen desaturation has resolved and the neonate is ready to be weaned from Noxivent™ therapy. Doses greater than 20 ppm are not recommended [see Warnings and Precautions (5.2)].
Training in Administration
The user of Noxivent™ and Nitric Oxide Delivery Systems must satisfactorily complete a comprehensive periodic training program for health care professionals provided by the delivery system and drug manufacturers. Health professional staff that administers nitric oxide therapy have access to supplier-provided 24 hour/365 days per year technical support on the delivery and administration of Noxivent™ at 1-833-669-8368.
Nitric Oxide Delivery Systems
Noxivent™ must be administered using a calibrated NOxBOXi®. Only validated ventilator systems should be used in conjunction with Noxivent™. Consult the Nitric Oxide Delivery System label or call 833-669-8368/visit linde.com for a current list of validated systems. Keep available a backup battery power supply and an independent reserve nitric oxide delivery system to address power and system failures.
Measure methemoglobin within 4-8 hours after initiation of treatment with Noxivent™ and periodically throughout treatment [see Warnings and Precautions (5.2)]. Monitor for PaO2 and inspired NO2 during Noxivent™ administration [see Warnings and Precautions 5.3)].
Weaning and Discontinuation
Avoid abrupt discontinuation of Noxivent™ [see Warnings and Precautions (5.1)]. To wean Noxivent™, downtitrate in several steps, pausing several hours at each step to monitor for hypoxemia.
More about Noxivent (nitric oxide)
- Side Effects
- During Pregnancy or Breastfeeding
- Drug Interactions
- Drug class: miscellaneous respiratory agents
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.