Moderna COVID-19 Vaccine Dosage

Generic name: CX-038839 OMICRON (XBB.1.5) 25ug in 0.25mL
Dosage form: injection, suspension
Drug class: Viral vaccines

Medically reviewed by Drugs.com. Last updated on Nov 1, 2023.

For intramuscular injection only.

2.1 Preparation for Administration

•: Moderna COVID-19 Vaccine single dose vials contain a frozen suspension that does not contain a preservative and must be thawed prior to administration.
•: Thaw each vial before use following the instructions below.

Thaw in Refrigerator	Thaw at Room Temperature
Thaw between 2°C to 8°C (36°F to 46°F) for 45 minutes. Let each vial stand at room temperature for 15 minutes before administering.	Alternatively, thaw between 15°C to 25°C (59°F to 77°F) for 15 minutes.

•: After thawing, do not refreeze.
•: Swirl vial gently after thawing and between each withdrawal. Do not shake. Do not dilute the vaccine.
•: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
•: Moderna COVID-19 Vaccine is a white to off-white suspension. It may contain white or translucent product-related particulates. Do not administer if vaccine is discolored or contains other particulate matter.
•: Withdraw a single 0.25 mL dose using a sterile needle and syringe.
•: Discard the vial and excess volume after extracting a single dose.

Administration

Administer the 0.25 mL dose of Moderna COVID-19 Vaccine intramuscularly.

2.3 Dose and Schedule

Individuals 6 Months Through 4 Years of Age by Moderna COVID-19 Vaccination Status

Number of Previous Doses of Moderna COVID-19 Vaccine(s)a	Moderna COVID-19 Vaccine (2023-2024 Formula) Dosing Regimen, Dose and Scheduleb
0c	2 doses,d 0.25 mL each Dose 1: month 0 Dose 2: month 1
1	Single Dose, 0.25 mL One month after receipt of a previous dose of Moderna COVID-19 vaccinea
≥2	Single dose, 0.25 mL ≥2 months after receipt of the last previous dose of Moderna COVID-19 vaccinea

a Previous dose(s) of Moderna COVID-19 vaccine(s) refers to Moderna COVID-19 Vaccine (Original monovalent) and Moderna COVID-19 Vaccine, Bivalent (Original and Omicron BA.4/BA.5). These vaccines are no longer authorized for use in the United States.
b For individuals with certain kinds of immunocompromise previously vaccinated with a Moderna COVID-19 vaccine, see text following the tables for dosing information.
c Not previously vaccinated with any COVID-19 vaccine.
d Individuals turning from 4 years to 5 years of age during the vaccination series should receive both doses with Moderna COVID-19 Vaccine (2023-2024 Formula).

Individuals 5 Years Through 11 Years of Age Irrespective of COVID-19 Vaccination Status

Moderna COVID-19 Vaccine (2023-2024 Formula)

Dosing Regimen, Dose and Schedulea

Single dose, 0.25 mL

If previously vaccinated, ≥2 months after receipt of the last previous dose of COVID-19 vaccinea,b

a For individuals with certain kinds of immunocompromise, see text following tables for dosing information.
b COVID-19 vaccine refers to the monovalent COVID-19 vaccines (original) and the bivalent COVID-19 vaccines (Original and Omicron BA.4/BA.5). These vaccines are no longer authorized for use in the United States.

Individuals 6 Months through 11 Years of Age with Certain Kinds of Immunocompromise

Individuals 6 months through 11 years of age with certain kinds of immunocompromise1 should complete at least a three-dose series with a COVID-19 vaccine, each dose one month apart.2 At least 1 dose should be with a COVID-19 vaccine (2023-2024 Formula).

•: If previously not vaccinated, complete the three-dose series with Moderna COVID-19 Vaccine (2023-2024 Formula).
•: If previously vaccinated with one or two dose(s) of Moderna COVID-19 Vaccine (Original monovalent) and/or the Moderna COVID-19 Vaccine, Bivalent, complete the remaining dose(s) in the three-dose series with Moderna COVID-19 Vaccine (2023-2024 Formula).
•: If previously vaccinated with three or more doses, administer a single dose of Moderna COVID-19 Vaccine (2023-2024 Formula) at least two months following the last previous dose.3,4

An additional dose of Moderna COVID-19 Vaccine (2023-2024 Formula) may be administered at least 2 months following the last dose of a COVID-19 vaccine (2023-2024 Formula).5,6 Additional doses of Moderna COVID-19 Vaccine (2023-2024 Formula) may be administered at the discretion of the healthcare provider, taking into consideration the individual’s clinical circumstances. The timing of the additional doses may be based on the individual’s clinical circumstances.

1: Certain kinds of immunocompromise refers to individuals who have undergone solid organ transplantation, or who are diagnosed with conditions that are considered to have an equivalent level of immunocompromise.
2: COVID-19 vaccine, each dose of the three-doses series given one month apart, refers to Moderna COVID-19 vaccines. Individuals turning from 11 to 12 years of age during the vaccination series may complete the series with doses of Moderna COVID-19 Vaccine (2023-2024 Formula).
3: For immunocompromised individuals 6 months through 4 years of age, the last previous dose refers to the last dose of Moderna COVID-19 Vaccine (Original monovalent) or Moderna COVID-19 Vaccine, Bivalent which are no longer authorized for use in the U.S.
4: For immunocompromised individuals 5 years through 11 years of age, the last previous dose refers to the last dose of a COVID-19 vaccine (Original monovalent) or bivalent COVID-19 vaccine which are no longer authorized for use in the U.S.
5: For immunocompromised individuals 6 months through 4 years of age, the last dose of a COVID-19 vaccine (2023-2024 Formula) refers to a dose with Moderna COVID-19 Vaccine (2023-2024 Formula).
6: For immunocompromised individuals 5 years through 11 years of age, the last dose of a COVID-19 vaccine (2023-2024 Formula) refers to a dose with Pfizer-BioNTech COVID-19 Vaccine (2023-2024 Formula) or Moderna COVID-19 Vaccine (2023-2024 Formula).