Lysodren Dosage
Medically reviewed by Drugs.com. Last updated on Jun 25, 2021.
Generic name: mitotane 500mg
Dosage form: tablet
Recommended Dose
The recommended initial dose of LYSODREN is 2 g to 6 g orally, in three or four divided doses per day. Increase doses incrementally to achieve a blood concentration of 14 to 20 mg/L, or as tolerated.
LYSODREN is a cytotoxic drug. Follow applicable special handling and disposal procedures.
Dose Modifications
Adrenal Crisis in the Setting of Shock or Severe Trauma
Discontinue LYSODREN until recovery [see Warnings and Precautions (5.1)].
Central Nervous System (CNS) Toxicity
Discontinue LYSODREN until symptoms resolve. Seven to 10 days after symptoms resolve, restart at a lower dose (for example, decrease by 500-1000 mg) [see Warnings and Precautions (5.2)].
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