Heparin / Taurolidine Catheter Lock Solution Dosage

Usual Adult Dose for Chronic Central Venous Catheterization

Instill a sufficient amount of catheter lock solution (heparin 1000 units/mL-taurolidine 13.5 mg/mL) into each catheter lumen at the conclusion of every hemodialysis session.

Comments:

• Use a 3 mL or 5 mL vial of lock solution depending on volume of the catheter lumens.
• This drug is intended only for instillation into a central venous catheter (CVC); do NOT administer systemically or as catheter lock flush product.
• Aspirate and discard this solution from the catheter before the next hemodialysis (HD) session.
• Limitations of use: Safety and efficacy have not been established in populations other than adult patients with kidney failure receiving chronic HD through a CVC.

Use: To reduce the incidence of catheter-related bloodstream infections in patients with kidney failure receiving chronic HD through a central venous catheter CVC

Usual Adult Dose for Hemodialysis Anticoagulation

Instill a sufficient amount of catheter lock solution (heparin 1000 units/mL-taurolidine 13.5 mg/mL) into each catheter lumen at the conclusion of every hemodialysis session.

Comments:

• Use a 3 mL or 5 mL vial of lock solution depending on volume of the catheter lumens.
• This drug is intended only for instillation into a central venous catheter (CVC); do NOT administer systemically or as catheter lock flush product.
• Aspirate and discard this solution from the catheter before the next hemodialysis (HD) session.
• Limitations of use: Safety and efficacy have not been established in populations other than adult patients with kidney failure receiving chronic HD through a CVC.

Use: To reduce the incidence of catheter-related bloodstream infections in patients with kidney failure receiving chronic HD through a central venous catheter CVC

Usual Adult Dose for Infection Prophylaxis

Instill a sufficient amount of catheter lock solution (heparin 1000 units/mL-taurolidine 13.5 mg/mL) into each catheter lumen at the conclusion of every hemodialysis session.

Comments:

• Use a 3 mL or 5 mL vial of lock solution depending on volume of the catheter lumens.
• This drug is intended only for instillation into a central venous catheter (CVC); do NOT administer systemically or as catheter lock flush product.
• Aspirate and discard this solution from the catheter before the next hemodialysis (HD) session.
• Limitations of use: Safety and efficacy have not been established in populations other than adult patients with kidney failure receiving chronic HD through a CVC.

Use: To reduce the incidence of catheter-related bloodstream infections in patients with kidney failure receiving chronic HD through a central venous catheter CVC

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Known heparin-induced thrombocytopenia
• Known hypersensitivity to taurolidine, heparin or the citrate excipient, or pork products

Safety and efficacy have not been established in patients younger than 18 years, or for populations other than adult patients with kidney failure receiving chronic HD through a CVC

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For instillation into CVCs only (not for systemic use)
• To administer, withdraw a sufficient volume from the vial using a sterile needle and syringe to fill the catheter lumens.
• Prior to initiation of the next HD session, this solution should be aspirated from the catheter and discarded.
• If solution cannot be aspirated, continue with standard of care CVC preparation and flush with normal saline. If a catheter malfunction is suspected, appropriate standard of care measures should be instituted.
• Each single-dose vial is designed for single-patient use with a single instillation in the CVC; discard any unused product.
• This drug should not be used as a catheter lock flush.

Storage requirements:

• Store at a controlled room temperature of 20C to 25C (68F to 77F); excursions are permitted from 15C to 30C (59F to 86F).
• Vials must be stored in the manufacturer carton prior to use.
• Do not freeze.

General:

• Vials of this product are available as 3 mL (heparin 3000 USP units-taurolidine 40.5 mg) or 5 mL (heparin 5000 USP units-taurolidine 67.5 mg).

Patient advice:

• Read the US FDA-approved patient labeling, if available.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer