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Fomivirsen Ophthalmic Dosage

Applies to the following strengths: 6.6 mg/mL

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for CMV Retinitis

330 mcg (0.05 mL) by intravitreal injection into the affected eye for both induction and maintenance. The induction phase consists of one injection every other week for two doses. Thereafter, maintenance doses should be administered once every four weeks.

Disease progression that occurs during maintenance therapy may require a reinstitution of induction therapy to restore disease control.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

Ocular inflammation (uveitis) occurs in approximately 25% of patients, particularly during induction dosing. Topical corticosteroids may be necessary to treat the inflammation so that fomivirsen therapy may continue. Once the CMV retinitis is under control, an interruption of therapy may be worthwhile if the patient has an unacceptable level of inflammation.

Dialysis

No adjustment recommended

Other Comments

Fomivirsen intravitreal injection is a localized treatment for CMV retinitis. Fomivirsen therapy does not treat or prevent systemic and extraocular CMV disease or disease in the untreated eye.

Treatment with fomivirsen intravitreal injection is not recommended for patients who have recently (within the last 2 to 4 weeks) been treated with either intravenous or intravitreal cidofovir because of the risk of excessive ocular inflammation.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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