Flotufolastat F 18 Dosage

Usual Adult Dose for:

Prostate Cancer

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Prostate Cancer

296 MBq intravenously (8 mCi) as a slow intravenous injection.

Comments:

Calculate the necessary volume to administer based on the calibration time and required dose.
The recommended maximum volume of undiluted drug is 5 mL.
Use this radiopharmaceutical within 10 hours from end of synthesis.

Use:
For PET of PSMA positive lesions in men with prostate cancer:

with suspected metastasis who are candidates for initial definitive therapy
with suspected recurrence based on elevated serum prostate-specific antigen (PSA) levels

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

Physicians experienced in the safe use of radionuclides and who have been approved by the appropriate governmental agency should handle this drug.
Make sure safe drug handling and patient preparation procedures are followed to protect patients and health care providers from unintentional radiation exposure. Use waterproof gloves, effective radiation shielding, including syringe shields, and other appropriate safety measures.
Inspect for particulate matter and discoloration before administration.
Do not use the drug if the solution contains particulate matter or is discolored.

Storage requirements:

Store at 20C to 25C (68F to 77F) in the original container with appropriate shielding to protect from radiation.

Reconstitution/preparation techniques:

The manufacturer product information should be consulted.

General:

Tumors that do not express PSMA will not be visualized.

Patient advice:

Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
Stay well hydrated before dose administration.
Urinate immediately prior to image acquisition and often after administration to reduce radiation exposure.