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Datopotamab Deruxtecan Dosage

Medically reviewed by Drugs.com. Last updated on Feb 18, 2025.

Applies to the following strengths: dlnk 100 mg

Usual Adult Dose for Breast Cancer

6 mg/kg IV every 3 weeks (21-day cycle)
Maximum dose: 540 mg/dose
Duration of therapy: Until disease progression or unacceptable toxicity

Comments:


Use: For the treatment of patients with unresectable or metastatic, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative (immunohistochemistry [IHC] 0, IHC 1+, or IHC 2+/in situ hybridization [ISH]-) breast cancer who have received prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 to less than 90 mL/min): No adjustment recommended
Severe renal dysfunction (CrCl less than 30 mL/min): Data not available

Comments:

Liver Dose Adjustments

Mild liver dysfunction (total bilirubin up to 1 times the upper limit of normal [1 x ULN] and AST greater than ULN or total bilirubin greater than 1 to 1.5 x ULN and any AST): No adjustment recommended
Moderate liver dysfunction (total bilirubin greater than 1.5 to 3 x ULN and any AST): Limited data available; monitoring recommended
Severe liver dysfunction (total bilirubin greater than 3 x ULN and any AST): Data not available

Comments:

Dose Adjustments

DOSAGE MODIFICATIONS FOR ADVERSE REACTIONS:


Recommended Dose Reduction Levels:

Interstitial Lung Disease (ILD)/Pneumonitis:

Keratitis:

Stomatitis:

Infusion-Related Reactions:

Other Nonhematologic Adverse Reactions:

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Premedication and Concomitant Medications:

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.