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Dasiglucagon Dosage

Medically reviewed by Drugs.com. Last updated on Apr 27, 2021.

Applies to the following strengths: 0.6 mg/0.6 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypoglycemia

0.6 mg subcutaneously once into lower abdomen, buttocks, thigh, or outer upper arm

If there has been no response after 15 minutes, a second 0.6 mg dose may be administered

Comments:

  • Patients/caregivers should be familiar with instructions for use; this drug should be administered as soon as possible when severe hypoglycemia is recognized.
  • Call for emergency assistance immediately after administering dose.
  • Once patient has responded to treatment, oral carbohydrates should be given to restore liver glycogen stores.

Use: For the treatment of severe hypoglycemia in patients with diabetes.

Usual Pediatric Dose for Hypoglycemia

6 years or older: 0.6 mg subcutaneously once into lower abdomen, buttocks, thigh, or outer upper arm

If there has been no response after 15 minutes, a second 0.6 mg dose may be administered

Comments:

  • Patients/caregivers should be familiar with instructions for use; this drug should be administered as soon as possible when severe hypoglycemia is recognized.
  • Call for emergency assistance immediately after administering dose.
  • Once patient has responded to treatment, oral carbohydrates should be given to restore liver glycogen stores.

Use: For the treatment of severe hypoglycemia in pediatric patients 6 years or older with diabetes.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

CONTRAINDICATIONS:

  • Pheochromocytoma
  • Insulinoma

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • For subcutaneous administration only
  • Inject into outer upper arms, lower abdomen, front or back of thighs, or buttocks; roll back clothing to expose bare skin; do not inject through clothes
  • The autoinjector and prefilled syringe each contain a single dose; do not reuse
  • Review instructions for use with patient/caregivers prior to, and each time medicine is dispensed

Storage requirements:
  • Store in refrigerator 36F to 46F (2C to 8C) in red protective case; do not freeze
  • May store at room temperature (68F to 77F [20C to 25C]) for up to 12 months; do not return to refrigerator after storing at room temperature
  • Upon removal from refrigerator, date label with new expiration date

Reconstitution/preparation techniques:
Consult instructions for use included in packaging; be familiar with use before an emergency occursAUTOINJECTOR: Pull gray cap off, push and hold straight down on skin until the yellow needle guard is fully pressed down (you may hear a click); keep holding down for 10 seconds and/or until the medicine window turns red (you may hear a second click); remove by lifting straight up; dispose of in a sharps containerPREFILLED SYRINGE: Remove gray needle cover, pinch skin, and insert entire needle into skin at a 45-degree angle, release skin, and slowly press plunger until plunger rod stops; remove needle carefully; dispose of in a sharps container

General:
  • The inside of the gray cap on the prefilled syringe and autoinjector contains a dry natural rubber (a derivative of latex).
  • Patients/caregivers should be familiar with administration and management of severe hypoglycemia prior to an emergency; emergency help should be sought after administration as hypoglycemia may occur after treatment.
  • This product has a shelf-life of 36 months at refrigerated temperatures and is stable for up to 12 months at room temperature.

Monitoring:
  • Blood glucose should be monitored to ensure efficacy; frequent monitoring of blood glucose should occur after a severe hypoglycemic episode.

Patient advice:
  • Patients/caregivers should be instructed to read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
  • Patients/caregivers should be able to recognize the signs and symptoms of severe hypoglycemia and know the risks of prolonged hypoglycemia.
  • Patients/caregivers should understand the risk of allergic reactions and seek immediate medical attention if symptoms of a serious hypersensitivity reaction develop.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.