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Dasiglucagon

Generic name: dasiglucagon [ DAS-i-GLOO-ka-gon ]
Brand names: Zegalogue Autoinjector, Zegalogue Prefilled Syringe
Dosage form: subcutaneous solution (0.6 mg/0.6 mL)
Drug class: Glucose elevating agents

Medically reviewed by Drugs.com on Apr 16, 2021. Written by Cerner Multum.

What is dasiglucagon?

Dasiglucagon is used to treat very low blood sugar (severe hypoglycemia) in adults and children at least 6 years old.

Dasiglucagon may also be used for purposes not listed in this medication guide.

Warnings

Be sure you and your caregivers know how to give a dasiglucagon injection before you need to use it. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

Before taking this medicine

You should not use dasiglucagon if you are allergic to it, or if you have:

  • a tumor of the pancreas (insulinoma); or

  • a tumor of the adrenal gland (pheochromocytoma).

Tell your doctor if you have:

  • any tumor of the pancreas;

  • chronic low blood sugar;

  • adrenal gland problems;

  • a latex allergy; or

  • if you have not recently eaten on a regular basis.

Do not give dasiglucagon to a child without medical advice.

Tell your doctor if you are pregnant or breastfeeding.

Dasiglucagon is not expected to harm an unborn baby, but quickly treating hypoglycemia would outweigh any risks posed by using dasiglucagon.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

How should I use dasiglucagon?

Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

Dasiglucagon is injected under the skin. You will be shown how to use emergency dasiglucagon injections for severe hypoglycemia. Call your doctor after each time you use a dasiglucagon injection.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Be sure you and your caregivers know how to give a dasiglucagon injection before you need to use it. The correct dose for a child is the same as that for an adult dose. Follow your doctor's dosing instructions very carefully.

After the injection, you should eat a fast-acting source of sugar (fruit juice, glucose gel, hard candy, raisins, or non-diet soda) and then eat a snack or small meal such as cheese or peanut butter and crackers.

If you are a caregiver, get emergency medical help after giving a dasiglucagon injection. If the patient does not improve within 15 minutes, you may need to give a second injection.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

To keep from having severe hypoglycemia, follow your diet, medication, and exercise routines very closely.

Store in the refrigerator, away from the cooling element. Do not freeze.

You may also store dasiglucagon at room temperature but you must use the medicine within 12 months or throw it away. Protect from light by storing the medicine in the protective case. Do not put the medicine back into a refrigerator after storing it at room temperature.

Do not use this medicine after the expiration date on the label has passed.

What happens if I miss a dose?

Since dasiglucagon is used as needed, it does not have a daily dosing schedule.

Call your doctor promptly if symptoms do not improve after using dasiglucagon.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, fast heartbeats, or high blood pressure.

What should I avoid while using dasiglucagon?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dasiglucagon side effects

Get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; difficulty breathing; fast or slow heartbeat; swelling of your face, lips, tongue, or throat.

Dasiglucagon may cause serious side effects. Call your doctor at once if you have:

  • severe headache, blurred vision, pounding in your neck or ears; or

  • new or ongoing low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky.

Common side effects of dasiglucagon may include:

  • nausea, vomiting, diarrhea;

  • headache;

  • pain where an injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dasiglucagon dosing information

Usual Adult Dose for Hypoglycemia:

0.6 mg subcutaneously once into lower abdomen, buttocks, thigh, or outer upper arm

If there has been no response after 15 minutes, a second 0.6 mg dose may be administered

Comments:
-Patients/caregivers should be familiar with instructions for use; this drug should be administered as soon as possible when severe hypoglycemia is recognized.
-Call for emergency assistance immediately after administering dose.
-Once patient has responded to treatment, oral carbohydrates should be given to restore liver glycogen stores.

Use: For the treatment of severe hypoglycemia in patients with diabetes.

Usual Pediatric Dose for Hypoglycemia:

6 years or older: 0.6 mg subcutaneously once into lower abdomen, buttocks, thigh, or outer upper arm

If there has been no response after 15 minutes, a second 0.6 mg dose may be administered

Comments:
-Patients/caregivers should be familiar with instructions for use; this drug should be administered as soon as possible when severe hypoglycemia is recognized.
-Call for emergency assistance immediately after administering dose.
-Once patient has responded to treatment, oral carbohydrates should be given to restore liver glycogen stores.

Use: For the treatment of severe hypoglycemia in pediatric patients 6 years or older with diabetes.

What other drugs will affect dasiglucagon?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect dasiglucagon, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.