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Chenodeoxycholic Acid Dosage

Medically reviewed by Last updated on Apr 8, 2024.

Applies to the following strengths: 250 mg

Usual Adult Dose for Gallbladder Disease

Initial dose: 250 mg orally 2 times a day
Maintenance dose: 13 to 16 mg/kg/day in 2 divided doses
Duration of therapy: 24 months


Use: Patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease/age

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Serum aminotransferase level monitoring: Monthly for the first 3 months, then every 3 months thereafter.

Dose Adjustments

Cholesterol levels: Treatment discontinuation should be considered in patients if cholesterol levels rise above acceptable age-adjusted limits.

Diarrhea occurring during treatment: Temporarily adjust the dose until symptoms abate, then continue treatment with the previous dose.

Lack of response: Treatment should be discontinued if there is no response by 18 months.



Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:

Reconstitution/preparation techniques:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.