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Botulinum Toxin Type B Dosage

Applies to the following strength(s): 5000 units/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cervical Dystonia

Initial: The dose should be individualized based on the patient's head and neck position, localization of pain, muscle hypertrophy, patient response, and adverse event history.

Patients with a prior history of tolerating botulinum toxin injections: 2500 to 5000 units (0.5 to 1.0 mL) divided among affected muscles.

Patients with no history of botulinum toxin type B: use should be at a lower dose, with subsequent dosing based on individual response.

Clinical improvement generally begins within the first two weeks after injection with studies showing the duration of effect to be between 12 and 16 weeks at doses of 5000 units or 10,000 units.

Usual Adult Dose for Hyperhidrosis

One method being used:
Initial: 2880 units per axilla intradermally for a total dose of 5760 units.

Dilute 5000 unit vial with 1.0 mL of saline in the vial. This dilution technique, when performed in the vial, yields 288 units per 0.1 mL of solution due to the slight overfill in the vial. With this dilution, inject 20 injections of 0.05 mL per axilla may be administered (with an approximate depth of 2 to 3 millimeters), resulting in a total dose of 2880 units per axilla. Injections should be scattered approximately every 2 square centimeters. If injection sites are marked in ink do not inject directly through the ink mark (to avoid a permanent tattoo mark).

Usual Adult Dose for Glabellar Lines

For glabellar lines and other facial wrinkles: 0.1 mL (500 units) intradermally.

Usual Pediatric Dose for Cervical Dystonia

The safety and efficacy of botulinum toxin type B for treatment of strabismus in children less than 12 years have not been established.

Initial: The dosage of botulinum toxin type B for the treatment of cervical dystonia should be individualized based on the patient's head and neck position, localization of pain, muscle hypertrophy, patient response, and adverse event history.

Patients with a prior history of tolerating botulinum toxin injections: 2500 to 5000 units (0.5 to 1.0 mL) intramuscularly divided among affected muscles.

Patients with no history of botulinum toxin type B: use should be at a lower dose, with subsequent dosing based on individual response.

Clinical improvement generally begins within the first two weeks after injection with studies showing the duration of effect to be between 12 and 16 weeks at doses of 5000 units or 10,000 units.

Usual Pediatric Dose for Hyperhidrosis

One method being used:
Initial: 2880 units per axilla intradermally for a total dose of 5760 units.

Dilute 5000 unit vial with 1.0 mL of saline in the vial. This dilution technique, when performed in the vial, yields 288 units per 0.1 mL of solution due to the slight overfill in the vial. With this dilution, inject 20 injections of 0.05 mL per axilla may be administered (with an approximate depth of 2 to 3 millimeters), resulting in a total dose of 2880 units per axilla. Injections should be scattered approximately every 2 square centimeters. If injection sites are marked in ink do not inject directly through the ink mark (to avoid a permanent tattoo mark).

Usual Pediatric Dose for Glabellar Lines

The safety and efficacy of botulinum toxin type B for treatment of strabismus in children less than 12 years have not been established.

For glabellar lines and other facial wrinkles: 0.1 mL (500 units) intradermally.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dialysis

No data available

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