Benzylpenicilloyl-Polylysine Dosage
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Penicillin Sensitization Testing
Puncture Skin Testing:
- The puncture technique should always be applied first.
- Skin testing is usually performed on the inner volar aspect of the forearm.
- A small drop of the skin test solution should be applied using a 22- to 28-gauge needle;
the drop of solution.
- A positive reaction consists of a pale wheal, sometimes with pseudopods, surrounding
more in diameter; erythema and variable degrees of itching may surround the wheal.
- If a positive response is evident, the solution should be wiped off immediately.
- If the puncture test is negative or equivocally positive (less than 5 mm wheal with little
test may be performed.
Intradermal Skin Testing:
- Prepare with an alcohol swab a skin test area on the upper, outer arm, sufficiently
necessary).
- A volume of skin test solution sufficient to raise a small bleb of about 3 mm in diameter,
syringe with a 3/8 to 5/8 inch long, 26- to 30-gauge short bevel needle.
- A like amount of saline or allergen-diluting solution should be injected with a separate
site, which should be reactionless.
- Repeat the test if the control site exhibits a wheal greater than 2 to 3 mm; consultation is necessary if the same reaction occurs after the test is repeated.
- Most skin reactions will develop within 5 to 15 minutes; the skin test response should
Interpretation of Intradermal Skin Test Response:
- Negative: No increase in size of original bleb or no greater reaction than the control site.
- Ambiguous: Wheal only slightly larger than original bleb with or without erythematous flare and slightly larger than control site; OR discordance between duplicate test sites.
- Positive: Itching and significant increase in size of original blebs to at least 5 mm; wheal may exhibit pseudopods and exceed 20 mm in diameter.
Comments: Do not administer the intradermally test to patients who have a positive reaction to the puncture test.
Use: Assessment of sensitization to penicillin (benzylpenicillin or penicillin G) in patients suspected to have clinical penicillin hypersensitivity.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration Advice:
- Skin test responses can be attenuated by interfering drugs (e.g., H1 antihistamines and vasopressors); use of this drug product should be delayed until the effects of such drugs have dissipated OR a separate skin test with histamine can be used to evaluate persistent antihistamine effects in vivo.
- Each ampule of this drug is for single patient use only and contains 0.25 mL, which is sufficient for both puncture and intradermal testing in duplicate in one patient; unused portions should be discarded.
- This drug product should be inspected visually for particulate matter and discoloration prior to administration.
Testing Technique:
- The manufacturer product information should be consulted.
Storage:
- Optimal storage is under refrigeration (2 to 8 Celsius).
- This drug product should be discarded if subjected to ambient temperatures for more than 24 hours or if particulate matter and/or discoloration are present.
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