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Albutein 5% Dosage

Generic name: Albumin Human 12.5g in 250mL
Dosage form: injection, solution
Drug class: Plasma expanders

Medically reviewed by Drugs.com. Last updated on Apr 4, 2022.

For Intravenous Use Only

Dosage

Adjust the concentration, dosage and infusion rate of the albumin preparation to the patient's individual requirements.

The dose required depends on the patient's body weight, severity of injury/illness and on continuing fluid and protein losses. Use adequacy of circulating blood volume, not plasma albumin levels, to determine the dose required.

Indication Dose
Hypovolemia Adults: Initial dose of 20 g.
If hemodynamic stability is not achieved within 15 to 30 minutes, an additional dose may be given.
Hemodilution may follow administration of ALBUTEIN 5%. Anemia resulting from hemorrhage should be corrected by administration of compatible red blood cells or compatible whole blood.
For acute liver failure: initial dose of 12 to 25 g. An infusion rate of 1-2 mL per minute is usually indicated.
For renal dialysis, the initial dose should not exceed 20 g and patients should be carefully observed for signs of fluid overload.
Cardiopulmonary bypass procedures Adults: Initial dose of 25 g. Additional amounts may be administered as clinically indicated.
Hypoalbuminemia Adults: 50 to 75 g
For pre- and post-operative hypoproteinemia: 50 to 75 g.
In burns, therapy usually starts with administration of large volumes of crystalloid solution to maintain plasma volume. After 24 hours: initial dose of 25 g and dose adjustment to maintain plasma protein concentration of 2.5 g per 100 mL or a serum protein concentration of 5.2 g per 100 mL.
Third space protein loss due to infection: initial dose of 50 to 100 g. An infusion rate of 1-2 mL per minute is usually indicated in the absence of shock. Treatment should always be guided by hemodynamic response.
Plasma exchange The dosage and infusion rate of ALBUTEIN 5% infused should be titrated to the volume of plasma removed during the procedure.

Administration

Intravenous use only

  • Some moisture or condensation may be observed in the protective overwrap. This is normal and does not affect the quality or safety of the albumin solution.
  • Check the inner bag for any leaks prior to use by squeezing it firmly. If leaks are detected, discard the solution.
  • ALBUTEIN 5% is a clear and slightly viscous solution. Visually inspect for particulate matter and discoloration prior to administration. Do not use if the solution is turbid, if there is sediment in the container, or if the seal is broken.
  • Warm product to room temperature before use if large volumes are administered.
  • Do not add supplementary medication.
  • Do not dilute with sterile water for injection [see Warnings and Precautions (5.6)].
  • ALBUTEIN 5% contains no preservatives. Once open, the product should be used within four hours. Discard unused portion.
  • For single use. Any unused solution must be discarded.
  • Adjust the infusion rate to the individual circumstances and the indication. In plasma exchange, adjust the infusion rate to the rate of plasma removal.

CAUTION: Do not use bags in series connections. Such use could result in air embolism due to residual air being drawn from the primary bag before the administration of the fluid from the secondary bag is complete.

  1. After checking that protective overwrap is not damaged, remove it by tearing the slots at either end (refer to Figure 1).

  2. Suspend the inner bag from the eyelet support (refer to Figure 2).

  3. Holding the protective safety shield at the infusion port of the inner bag with one hand, use the free hand to exert light force to turn the twist-off opening about 90 degrees until it leaves the port (refer to Figure 3).

  4. Attach either a non-vented or vented administration set (refer to Figure 4). Adjust the infusion rate to the individual circumstances and the indication. Refer to the complete directions of administration set used.
Figures 1-4

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.