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Zostavax (zoster vaccine live) Disease Interactions

There are 2 disease interactions with Zostavax (zoster vaccine live):

Major

Vaccination (Includes Zostavax) ↔ Infections

Severe Potential Hazard, High plausibility

Applies to: Fever, Infection - Bacterial/Fungal/Protozoal/Viral

Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.

References

  1. "Product Information. Cholera vaccine (cholera vaccine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. "Product Information. Pneumovax 23 (pneumococcal vaccine, polyvalent)." Merck & Co, Inc, West Point, PA.
  3. "Product Information. YF-Vax (yellow fever vaccine)." sanofi pasteur, Swiftwater, PA.
  4. "Product Information. Typhim Vi (typhoid vaccine)." Connaught, Swiftwater, PA.
  5. "Product Information. Varivax (varicella virus vaccine live)." Merck & Co, Inc, West Point, PA.
  6. "Product Information. Attenuvax (measles virus vaccine, live, attenuated)." Merck & Co, Inc, West Point, PA.
  7. "Product Information. Engerix-B (hepatitis B vaccine)." SmithKline Beecham, Philadelphia, PA.
  8. "Product Information. Meruvax II (rubella virus vaccine, live)." Merck & Co, Inc, West Point, PA.
  9. "Product Information. Orimune (poliovirus vaccine, live, oral, trivalent)." Lederle Laboratories, Philadelphia, PA.
  10. "Product Information. Menomune-A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught, Swiftwater, PA.
  11. "Product Information. Mumpsvax (mumps virus vaccine (live).)." Merck & Co, Inc, West Point, PA.
  12. "Product Information. Omnihib (haemophilus b conjugate vaccine)." SmithKline Beecham, Philadelphia, PA.
  13. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases. 24th" Grove Village, IL: American Academy of Pediatrics (1997):
  14. "Product Information. Havrix (hepatitis A vaccine)." SmithKline Beecham, Philadelphia, PA.
  15. "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc, Lenoir, NC.
View all 15 references
Major

Varicella Vaccine (Includes Zostavax) ↔ Immunodeficiency

Severe Potential Hazard, High plausibility

Applies to: Immunodeficiency

In general, the use of varicella virus vaccine is contraindicated in patients with primary or acquired immunodeficiency or infection with HIV. Since varicella virus vaccine contains live attenuated virus, the absence of immune competence may potentiate the replication of vaccine virus, increase adverse host reactions, and compromise serum antibody response. The vaccine should not be administered to immunosuppressed or immunodeficient individuals and those receiving immunosuppressive therapy, including individuals receiving immunosuppressive doses of corticosteroids as it may cause an extensive vaccine-associated rash or disseminated disease in these individuals.

References

  1. "Product Information. Varivax (varicella virus vaccine live)." Merck & Co, Inc, West Point, PA.
  2. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases. 24th" Grove Village, IL: American Academy of Pediatrics (1997):

Zostavax (zoster vaccine live) drug Interactions

There are 221 drug interactions with Zostavax (zoster vaccine live)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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