Romvimza Disease Interactions
There are 2 disease interactions with Romvimza (vimseltinib).
Vimseltinib (applies to Romvimza) liver disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Biliary Obstruction, Hyperbilirubinemia
Vimseltinib should be avoided in patients with preexisting increased serum transaminases; total bilirubin or direct bilirubin (greater than 1 times the upper limit of normal [1 x ULN]); or active liver or biliary tract disease, including alkaline phosphatase. Liver tests (including AST, ALT, total bilirubin, direct bilirubin, alkaline phosphatase, and GGT) should be monitored before starting vimseltinib, twice a month for the first 2 months of therapy, every 3 months for the first year of therapy, and as clinically indicated thereafter. Vimseltinib has not been studied in patients with moderate (bilirubin greater than 1.5 to 3 x ULN and any AST) or severe (bilirubin greater than 3 x ULN and any AST) liver dysfunction. No dose adjustment is recommended for patients with mild (bilirubin up to 1 x ULN and AST greater than 1 x ULN or bilirubin greater than 1 to 1.5 x ULN and any AST) liver dysfunction.
Vimseltinib (applies to Romvimza) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
During vimseltinib treatment, renal function should be assessed using alternative measures that are not based on serum creatinine. In 1 study, serum creatinine increased by a mean of 19 mcmol/L compared to baseline. These increases in serum creatinine may not be associated with changes in renal function but may be due to inhibition of renal tubular secretion transporters. Creatinine increases reversed when vimseltinib was discontinued. The effect of severe renal dysfunction (estimated GFR less than 30 mL/min) on vimseltinib pharmacokinetics is unknown.
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Romvimza drug interactions
There are 136 drug interactions with Romvimza (vimseltinib).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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