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Romvimza

Pronunciation: rom-vim-zah
Generic name: vimseltinib
Dosage form: oral capsule (14 mg, 20 mg, 30 mg)
Drug class: Miscellaneous antineoplastics

Medically reviewed by Carmen Pope, BPharm. Last updated on Apr 4, 2025.

What is Romvimza?

Romvimza is used to treat symptomatic tenosynovial giant cell tumor (TGCT) in adults when surgery may make the symptoms worse or cause severe problems. It is an oral capsule that is taken 2 times a week.

Romvimza is a kinase inhibitor with a mechanism that involves inhibition of colony-stimulating factor 1 receptor (CSF1R), a key regulator in multiple biological processes, particularly in the immune system. CSF1R signaling can become dysregulated in various conditions, including neurodegenerative diseases and cancer.

Romvimza (vimseltinib) gained FDA approval on February 14, 2025.

Side effects

The most common side effects of Romvimza are:

Serious side effects and warnings

Romvimza can cause serious side effects, including:

Your healthcare provider will do blood tests to check for liver problems before starting treatment with Romvimza, 2 times each month for the first 2 months of treatment, then 1 time every 3 months for the first year of treatment, and as clinically indicated thereafter.

If you develop liver problems during treatment with Romvimza, your healthcare provider may temporarily stop treatment, decrease your dose, or permanently stop treatment depending on how severe your liver problems are. Tell your healthcare provider right away if you develop any signs or symptoms of liver problems during treatment with Romvimza including:

Romvimza may cause fertility problems, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of Romvimza. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking

Before taking Romvimza, tell your healthcare provider about all of your medical conditions, including if you:

Pregnancy

Romvimza can harm your unborn baby. Females who can become pregnant:

Males with female partners who can become pregnant:

Breastfeeding

It is not known if Romvimza passes into your breast milk. Do not breastfeed during treatment with Romvimza and for 1 month after the last dose.

How should I take Romvimza?

Take Romvimza exactly as your healthcare provider tells you to. Do not change your dose or stop taking Romvimza unless your healthcare provider tells you to.

If you vomit within 30 minutes of taking a dose of Romvimza, take another dose. If you vomit more than 30 minutes after taking your dose, do not take another dose and take the next dose on its regularly scheduled day.

Dosing information

Recommended Adult Dosage for TGCT: 30 mg orally twice weekly, with a minimum of 72 hours between doses as described in the blister package.

See the full Romvimza Prescribing Information for dosage modifications due to liver disease and drug interactions.

What happens if I miss a dose?

If you miss a dose of Romvimza by 48 hours or less, take the missed dose as soon as possible and take the next dose on its regularly scheduled day.

If you miss your dose by more than 48 hours, skip the missed dose, and take the next dose on its regularly scheduled day.

What happens if I overdose?

If you take more than the prescribed dose of Romvimza, call your healthcare provider.

What other drugs will affect Romvimza?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take:

Taking Romvimza with certain other medicines may affect the way that Romvimza or the other medicine works and may increase your risk of side effects. Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.

Does Romvimza interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Storage

Store Romvimza capsules at room temperature between 68ºF to 77ºF (20ºC to 25ºC) in the original blister pack until you are ready to take them. Do not store in another container.

Keep out of the reach of children.

What are the ingredients in Romvimza?

Active ingredient: vimseltinib

Inactive ingredients: crospovidone, lactose monohydrate, and magnesium stearate

The capsule shells contain:

The ink contains black iron oxide, potassium hydroxide, propylene glycol, shellac, and strong ammonia solution.

Available as 14 mg, 20 mg, and 30 mg capsules.

Manufacturer

Romvimza is manufactured by Deciphera Pharmaceuticals, LLC, based in Waltham, MA 02451.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.