Telotristat Disease Interactions

The use of telotristat reduces bowel movement frequency and may cause gastrointestinal effects including, constipation, intestinal perforation and obstruction. It is recommended to monitor for the development of constipation and/or severe, persistent, or worsening abdominal pain in patients taking telotristat and to discontinue its use if severe constipation or severe persistent or worsening abdominal pain develops. Care is recommended when using telotristat in patients suffering from constipation. .

Population pharmacokinetic analysis showed that mild hepatic impairment does not affect the pharmacokinetics of telotristat. Care is recommended when using telotristat in patients with moderate or severe hepatic impairment as this agent has not been studied in this patient population.

Population pharmacokinetic (PK) analysis showed that creatine clearance does not affect the PK of telotristat. Care is recommended when using telotristat in patients with end-stage renal disease (ESRD) who require dialysis as this agent has not been studied in this patient population.