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Telotristat Disease Interactions

There are 3 disease interactions with telotristat.

Moderate

Telotristat (applies to telotristat) constipation

Moderate Potential Hazard, Moderate plausibility.

The use of telotristat reduces bowel movement frequency and may cause gastrointestinal effects including, constipation, intestinal perforation and obstruction. It is recommended to monitor for the development of constipation and/or severe, persistent, or worsening abdominal pain in patients taking telotristat and to discontinue its use if severe constipation or severe persistent or worsening abdominal pain develops. Care is recommended when using telotristat in patients suffering from constipation. .

References

  1. "Product Information. Xermelo (telotristat ethyl)." Lexicon Pharmaceuticals, Inc. (2017):
Moderate

Telotristat (applies to telotristat) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Population pharmacokinetic analysis showed that mild hepatic impairment does not affect the pharmacokinetics of telotristat. Care is recommended when using telotristat in patients with moderate or severe hepatic impairment as this agent has not been studied in this patient population.

References

  1. "Product Information. Xermelo (telotristat ethyl)." Lexicon Pharmaceuticals, Inc. (2017):
Moderate

Telotristat (applies to telotristat) renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: hemodialysis

Population pharmacokinetic (PK) analysis showed that creatine clearance does not affect the PK of telotristat. Care is recommended when using telotristat in patients with end-stage renal disease (ESRD) who require dialysis as this agent has not been studied in this patient population.

References

  1. "Product Information. Xermelo (telotristat ethyl)." Lexicon Pharmaceuticals, Inc. (2017):

Telotristat drug interactions

There are 348 drug interactions with telotristat.

Telotristat alcohol/food interactions

There are 2 alcohol/food interactions with telotristat.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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