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Sebelipase alfa Disease Interactions

There are 2 disease interactions with sebelipase alfa:

Major

Lysosomal Enzymes (Includes Sebelipase alfa) ↔ Hypersensitivity

Severe Potential Hazard, Moderate plausibility

Applies to: Pulmonary Impairment, Heart Disease

Patients with acute underlying respiratory illness or compromised cardiac and/or respiratory function may be at risk of serious exacerbation of their cardiac or respiratory symptoms due to hypersensitivity reactions during enzyme replacement therapy. Evaluation of cardiac function and airway patency should be considered before initiation of treatment. Appropriate medical support and monitoring measures should be readily available during enzyme replacement therapy, and some patients may require prolonged observation times that should be individualized based on the needs of the patient. Consider the risks and benefits of re-administering these agents following a severe reaction. Monitor patients, with appropriate resuscitation measures available, if the decision is made to re-administer the product.

Major

Sebelipase Alfa (Includes Sebelipase alfa) ↔ Hypersensitivity

Severe Potential Hazard, Moderate plausibility

Applies to: Anaphylaxis

Kanuma, the brand name of sebelipase alfa injection is produced in the egg whites of genetically engineered chickens. It is recommended to consider the risks and benefits of treatment in patients with known systemic hypersensitivity reactions to eggs or egg products.

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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