Skip to Content

Kanuma (sebelipase alfa) Disease Interactions

There are 2 disease interactions with Kanuma (sebelipase alfa):

Major

Lysosomal enzymes (applies to Kanuma) hypersensitivity

Major Potential Hazard, Moderate plausibility. Applicable conditions: Pulmonary Impairment, Heart Disease

Patients with acute underlying respiratory illness or compromised cardiac and/or respiratory function may be at risk of serious exacerbation of their cardiac or respiratory symptoms due to hypersensitivity reactions during enzyme replacement therapy. Evaluation of cardiac function and airway patency should be considered before initiation of treatment. Appropriate medical support and monitoring measures should be readily available during enzyme replacement therapy, and some patients may require prolonged observation times that should be individualized based on the needs of the patient. Consider the risks and benefits of re-administering these agents following a severe reaction. Monitor patients, with appropriate resuscitation measures available, if the decision is made to re-administer the product.

Major

Sebelipase alfa (applies to Kanuma) hypersensitivity

Major Potential Hazard, Moderate plausibility. Applicable conditions: Anaphylaxis

Kanuma, the brand name of sebelipase alfa injection is produced in the egg whites of genetically engineered chickens. It is recommended to consider the risks and benefits of treatment in patients with known systemic hypersensitivity reactions to eggs or egg products.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.