Sapropterin Disease Interactions
There are 4 disease interactions with sapropterin:
Sapropterin (applies to sapropterin) gastritis
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Duodenitis/Gastritis
During clinical studies with sapropterin, gastritis was reported as a serious adverse reaction. Monitor patients for signs and symptoms of gastritis during treatment, and use with caution in patients with a history of gastritis.
Sapropterin (applies to sapropterin) liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Patients with liver impairment have not been evaluated in clinical trials with sapropterin. Hepatic damage has been associated in patients with impaired phenylalanine metabolism. Caution and monitoring is advised in patients with liver impairment who are receiving treatment with sapropterin.
Sapropterin (applies to sapropterin) neurological disorders
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neurologic Disorder
A 10-year sapropterin postmarketing-marketing safety surveillance program for a non-phenylketonuria indication, showed that a few patients with underlying neurological disorders experienced seizures, exacerbation of seizures, over-stimulation, and irritability especially when coadministered with levodopa. Patients with neurological disorders, especially those receiving levodopa should be monitored for changes in neurological status during treatment with sapropterin.
Sapropterin (applies to sapropterin) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Patients with renal impairment have not been evaluated in sapropterin clinical trials. Monitor patients who have renal impairment carefully if receiving treatment with sapropterin.
Sapropterin drug interactions
There are 20 drug interactions with sapropterin
Sapropterin alcohol/food interactions
There is 1 alcohol/food interaction with sapropterin
More about sapropterin
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- Drug class: miscellaneous metabolic agents
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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