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Rimantadine Disease Interactions

There are 3 disease interactions with rimantadine:

Moderate

Rimantadine (applies to rimantadine) liver disease

Moderate Potential Hazard, High plausibility.

Rimantadine is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with liver disease. One-half the usual dosage is recommended for patients with severe hepatic dysfunction.

References

  1. Wills RJ, Belshe R, Tomlinsin D, De Grazia F, Lin A, Wells S, Milazzo J, Berry C "Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease." Clin Pharmacol Ther 42 (1987): 449-54
  2. "Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.
Moderate

Rimantadine (applies to rimantadine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Rimantadine and its metabolites are excreted by the kidney. Patients with renal impairment may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with renal impairment. One-half the usual dosage is recommended for patients with severe renal dysfunction (CrCl <= 10 mL/min).

References

  1. Tominack RL, Wills RJ, Gustavson LE, Hayden FG "Multiple-dose pharmacokinetics of rimantadine in elderly adults." Antimicrob Agents Chemother 32 (1988): 1813-9
  2. Capparelli EV, Stevens RC, Chow MS, Izard M, Wills RJ "Rimantadine pharmacokinetics in healthy subjects and patients with end-stage renal failure." Clin Pharmacol Ther 43 (1988): 536-41
  3. Rubio FR, Fukuda EK, Garland WA "Urinary metabolites of rimantadine in humans." Drug Metab Dispos 16 (1988): 773-7
  4. "Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.
View all 4 references
Moderate

Rimantadine (applies to rimantadine) seizure disorders

Moderate Potential Hazard, Low plausibility. Applicable conditions: Seizures

Seizures have been reported in a few patients with a history of seizure disorders who were not receiving anticonvulsant medication while taking rimantadine. Therapy with rimantadine should be administered cautiously in patients with epilepsy or predisposed to seizures.

References

  1. "Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.
  2. Bentley DW, Karki SD, Betts RF "Rimantadine and seizures." Ann Intern Med 110 (1989): 323-4
  3. Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4

Rimantadine drug interactions

There are 14 drug interactions with rimantadine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.