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Rimantadine Disease Interactions

There are 3 disease interactions with rimantadine.

Moderate

Rimantadine (applies to rimantadine) liver disease

Moderate Potential Hazard, High plausibility.

Rimantadine is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with liver disease. One-half the usual dosage is recommended for patients with severe hepatic dysfunction.

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Moderate

Rimantadine (applies to rimantadine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Rimantadine and its metabolites are excreted by the kidney. Patients with renal impairment may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with renal impairment. One-half the usual dosage is recommended for patients with severe renal dysfunction (CrCl <= 10 mL/min).

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Moderate

Rimantadine (applies to rimantadine) seizure disorders

Moderate Potential Hazard, Low plausibility. Applicable conditions: Seizures

Seizures have been reported in a few patients with a history of seizure disorders who were not receiving anticonvulsant medication while taking rimantadine. Therapy with rimantadine should be administered cautiously in patients with epilepsy or predisposed to seizures.

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Rimantadine drug interactions

There are 15 drug interactions with rimantadine.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.