Quinacrine Disease Interactions
There are 4 disease interactions with quinacrine.
Aminoquinolines (applies to quinacrine) porphyria
Major Potential Hazard, Moderate plausibility.
The use of aminoquinolines in patients with porphyria may exacerbate the condition. Aminoquinolines should not be used in these patients unless the potential benefits are anticipated to outweigh the risks.
References (3)
- (2002) "Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals
- Liu AC (1995) "Hepatotoxic reaction to chloroquine phosphate in a patient with previously unrecognized porphyria cutanea tarda." West J Med, 162, p. 548-51
- (2022) "Product Information. Plaquenil (hydroxychloroquine)." Apothecon Inc
Aminoquinolines (applies to quinacrine) glucose-6-PD deficiency
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency
Hemolysis and acute renal failure have been reported during use of aminoquinolines in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Therapy with aminoquinolines should be administered cautiously in these patients. Blood cell counts and hemoglobin determinations should be performed regularly. Aminoquinoline therapy should be discontinued immediately if signs suggestive of hemolytic anemia occur, such as marked darkening of the urine or sudden decrease in hemoglobin concentration or erythrocytic count.
References (2)
- (2002) "Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals
- (2022) "Product Information. Plaquenil (hydroxychloroquine)." Apothecon Inc
Aminoquinolines (applies to quinacrine) hepatotoxicity
Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease, Alcoholism
Aminoquinolines may concentrate in the liver. Isolated cases of abnormal liver function and fulminant hepatic failure have been reported. Therapy with aminoquinolines should be administered cautiously in patients with hepatic disease or alcoholism and in patients receiving other hepatotoxic drugs. Periodic evaluation of hepatic function should be performed during prolonged therapy.
References (4)
- (2002) "Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals
- Liu AC (1995) "Hepatotoxic reaction to chloroquine phosphate in a patient with previously unrecognized porphyria cutanea tarda." West J Med, 162, p. 548-51
- (2022) "Product Information. Plaquenil (hydroxychloroquine)." Apothecon Inc
- Grossman I, Azaz-Livshits T, Fridlender Z, Muszkat M, Ben-Chetrit E (2000) "Mefloquine-induced acute hepatitis." Pharmacotherapy, 20, p. 1517-9
Aminoquinolines (applies to quinacrine) psoriasis
Moderate Potential Hazard, Moderate plausibility.
The use of aminoquinolines in patients with psoriasis may precipitate a severe attack of psoriasis. Aminoquinolines should not be used in these patients unless the potential benefits are anticipated to outweigh the risks.
References (7)
- Olsen TG (1981) "Chloroquine and psoriasis." Ann Intern Med, 94, p. 546-7
- Mallett R (1989) "Risks and benefits of prophylactic antimalarial drugs." Br Med J, 299, p. 1400
- Okor RS (1991) "Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy." J Clin Pharm Ther, 16, p. 463-5
- Kuflik EG (1980) "Effect of antimalarial drugs on psoriasis." Cutis, 26, p. 53-5
- Vestey JP, Savin JA (1992) "Psoriasis worsened by antimalarial prophylaxis." J Infect, 24, p. 211-2
- (2002) "Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals
- (2022) "Product Information. Plaquenil (hydroxychloroquine)." Apothecon Inc
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Quinacrine drug interactions
There are 13 drug interactions with quinacrine.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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