Proguanil Disease Interactions
There are 2 disease interactions with proguanil.
Proguanil (applies to proguanil) severe renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Atovaquone and Proguanil tablets are contraindicated for prophylaxis of P. falciparum malaria in patients with severe renal impairment (creatinine clearance <30 mL/min) because of pancytopenia in patients with severe renal impairment treated with proguanil. Use with caution for the treatment of malaria in patients with severe renal impairment, only if the benefits of the 3-day treatment regimen outweigh the potential risks associated with increased drug exposure. No dosage adjustments are needed in patients with mild (creatinine clearance 50 to 80 mL/min) or moderate (creatinine clearance 30 to 50 mL/min) renal impairment.
Proguanil (applies to proguanil) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
No proguanil dosage adjustments are needed in patients with mild or moderate hepatic impairment, however, no trials have been conducted in patients with severe hepatic impairment. Caution is advised, as elevated liver laboratory tests and cases of hepatitis and hepatic failure requiring liver transplantation have been reported with prophylactic use of atovaquone and proguanil hydrochloride tablets.
Switch to professional interaction data
Proguanil drug interactions
There are 36 drug interactions with proguanil.
More about proguanil
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Adoxa CK
Adoxa CK is used for acne, cervicitis, chancroid, gonococcal infection, uncomplicated
Adoxa TT
Adoxa TT is used for acne, cervicitis, chancroid, gonococcal infection, uncomplicated
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Daraprim
Daraprim is used for malaria prevention, pneumocystis pneumonia prophylaxis, toxoplasmosis ...
Doryx
Doryx is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Doxy 100
Doxy 100 is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Monodox
Monodox is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Oracea
Oracea is used to treat inflammation associated with rosacea in adults. Learn about side effects ...
Oraxyl
Oraxyl is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Vibramycin
Vibramycin is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.