Skip to main content

Pneumovax 23 Disease Interactions

There are 2 disease interactions with Pneumovax 23 (pneumococcal 23-polyvalent vaccine).


Pneumococcal 23 valent vaccine (applies to Pneumovax 23) cardiovascular disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Pulmonary Heart or Vascular Disease

Caution and appropriate monitoring should be exercised when administering pneumococcal 23 valent vaccine to individuals with severely compromised cardiovascular and/or pulmonary function in whom a systemic reaction would pose a significant risk.


  1. "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Company Inc (2022):

Vaccines (inactivated)/toxoids (applies to Pneumovax 23) immunodeficiency

Moderate Potential Hazard, High plausibility.

The expected serum antibody responses may not be obtained when vaccines and/or toxoids are administered to patients with primary or acquired immunodeficiency, including those with severe combined immunodeficiency, hypogammaglobulinemia or agammaglobulinemia, HIV infection, altered immune states (due to diseases such as leukemia, lymphoma, or generalized malignancy), or immunosuppression due to drug or other treatments (e.g., corticosteroids, alkylating agents, antimetabolites, or radiation).


  1. "Product Information. Tetanus Toxoid Adsorbed (tetanus toxoid)." Aventis Pharmaceuticals (2001):
  2. "Product Information. Typhim VI (typhoid vaccine, inactivated)." Apothecon Inc (2022):
  3. "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Company Inc (2022):
  4. "Product Information. Fluzone (influenza virus vaccine, inactivated)." Connaught Laboratories Inc
  5. "Product Information. Omnihib (haemophilus b conjugate vaccine (obsolete))." SmithKline Beecham
  6. "Product Information. Menomune A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught Laboratories Inc
  7. "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc (2001):
  8. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics (1997):
  9. "Product Information. Havrix (hepatitis A adult vaccine)." SmithKline Beecham
  10. "Product Information. Engerix-B (hepatitis B adult vaccine)." Apothecon Inc (2022):
  11. "Product Information. Gardasil (human papillomavirus vaccine)." Merck & Company Inc (2006):
  12. "Product Information. Cervarix (human papillomavirus vaccine)." GlaxoSmithKline (2009):
  13. "Product Information. Prevnar 13 (pneumococcal 13-valent conjugate vaccine)." Apothecon Inc (2022):
  14. "Product Information. Gardasil 9 (human papillomavirus vaccine)." Merck & Company Inc (2016):
View all 14 references

Pneumovax 23 drug interactions

There are 257 drug interactions with Pneumovax 23 (pneumococcal 23-polyvalent vaccine).

Report options

Share by QR Code
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.