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Piperazine Disease Interactions

There are 4 disease interactions with piperazine.

Major

Piperazine (applies to piperazine) liver disease

Major Potential Hazard, High plausibility.

The use of piperazine is contraindicated in patients with liver impairment. Approximately 25% of piperazine undergoes metabolism by the liver.

References

  1. (2001) "Product Information. Piperazine (piperazine)." Global Pharmaceutical Corporation
Major

Piperazine (applies to piperazine) renal dysfunction

Major Potential Hazard, High plausibility.

The use of piperazine is contraindicated in patients with renal dysfunction. Piperazine is primarily excreted unchanged in the urine.

References

  1. (2001) "Product Information. Piperazine (piperazine)." Global Pharmaceutical Corporation
Moderate

Anthelmintics (applies to piperazine) supportive therapy

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Malnourished, Dehydration, Anemia

Patients with anemia, dehydration, or malnutrition should receive supportive therapy for these complicating conditions prior to initiation of certain anthelmintic therapy.

References

  1. (2001) "Product Information. Mintezol (thiabendazole)." Merck & Co., Inc
  2. (2001) "Product Information. Antiminth (pyrantel)." Pfizer U.S. Pharmaceuticals Group
  3. (2001) "Product Information. Piperazine (piperazine)." Global Pharmaceutical Corporation
Moderate

Piperazine (applies to piperazine) seizure disorders

Moderate Potential Hazard, High plausibility. Applicable conditions: Seizures

The use of piperazine has rarely been associated with epileptiform convulsions. Therapy with piperazine should be administered cautiously in patients with preexisting seizure disorders.

References

  1. (2001) "Product Information. Piperazine (piperazine)." Global Pharmaceutical Corporation

Piperazine drug interactions

There are 15 drug interactions with piperazine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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