Piperazine Disease Interactions
There are 4 disease interactions with piperazine.
Piperazine (applies to piperazine) liver disease
Major Potential Hazard, High plausibility.
The use of piperazine is contraindicated in patients with liver impairment. Approximately 25% of piperazine undergoes metabolism by the liver.
Piperazine (applies to piperazine) renal dysfunction
Major Potential Hazard, High plausibility.
The use of piperazine is contraindicated in patients with renal dysfunction. Piperazine is primarily excreted unchanged in the urine.
Anthelmintics (applies to piperazine) supportive therapy
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Malnourished, Dehydration, Anemia
Patients with anemia, dehydration, or malnutrition should receive supportive therapy for these complicating conditions prior to initiation of certain anthelmintic therapy.
Piperazine (applies to piperazine) seizure disorders
Moderate Potential Hazard, High plausibility. Applicable conditions: Seizures
The use of piperazine has rarely been associated with epileptiform convulsions. Therapy with piperazine should be administered cautiously in patients with preexisting seizure disorders.
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Piperazine drug interactions
There are 15 drug interactions with piperazine.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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