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Pilocarpine Disease Interactions

There are 9 disease interactions with pilocarpine:

Major

Cholinergic agonist (applies to pilocarpine) bronchospasm

Major Potential Hazard, High plausibility. Applicable conditions: Asthma

The use of cholinergic agonists is contraindicated in patients with uncontrolled reactive airway disease. Cholinergic agonists inhibits the hydrolysis of acetylcholine. The enhanced effect of acetylcholine produces constriction of the bronchi, increased bronchial secretions, and bronchospasm.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (applies to pilocarpine) cardiac dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Ischemic Heart Disease, Hypertension, Hypotension, Heart Block

The use of cholinergic agonists, such as bethanechol and pilocarpine, is contraindicated in patients with pronounced bradycardia, hypotension/hypertension, coronary artery disease or conduction disorders.

References

  1. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
  2. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
Major

Cholinergic agonist (applies to pilocarpine) GI/bladder neck obstruction

Major Potential Hazard, High plausibility. Applicable conditions: Urinary Retention, Peptic Ulcer, Gastrointestinal Obstruction, Colitis/Enteritis (Noninfectious)

The use of cholinergic agonists is contraindicated in patients with peptic ulcers, mechanical GI obstruction, acute GI inflammatory conditions, or urinary obstruction. Cholinergic activity may result in an increase in gastric acid secretion, GI motility, and gastric contractions. In patients with urinary retention, urinary reflux may occur if the sphincter fails to relax when the bladder is contracted by cholinergic stimulation. The reflux of urine from the bladder can cause infection in the kidneys and upper urinary tract if bacteriuria is present.

References

  1. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
  2. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
Major

Cholinergic agonist (applies to pilocarpine) hyperthyroidism

Major Potential Hazard, High plausibility.

The use of cholinergic agents may be contraindicated in patients with hyperthyroidism. Atrial fibrillation has occurred in hyperthyroid patients administered a cholinergic agonist.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (applies to pilocarpine) parkinsonism

Major Potential Hazard, High plausibility.

The use of cholinergic agonists may be contraindicated in patients with parkinsonism. Cholinergic agonists directly stimulates the parasympathetic nervous system inducing acetylcholinergic effects. Symptoms of Parkinson's disease may be exacerbated.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (applies to pilocarpine) seizure disorders

Major Potential Hazard, High plausibility. Applicable conditions: Seizures

The use of cholinergic agonists may be contraindicated in patients with seizure disorders. Cholinomimetics have been associated with convulsions.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Pilocarpine (applies to pilocarpine) glaucoma

Major Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma (Narrow Angle), Uveitis (Anterior)

The use of pilocarpine is contraindicated in conditions where miosis is undesirable, such as acute iritis and in narrow-angle (angle closure) glaucoma.

Moderate

Pilocarpine (applies to pilocarpine) cholelithiasis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Biliary Obstruction

Pilocarpine should be administered with caution to patients with known or suspected cholelithiasis or biliary tract disease. Contractions of the gallbladder or biliary smooth muscle could precipitate complications including cholecystitis, cholangitis, and biliary obstruction.

Moderate

Pilocarpine (applies to pilocarpine) nephrolithiasis

Moderate Potential Hazard, Moderate plausibility.

Pilocarpine may increase ureteral smooth muscle tone and could theoretically precipitate renal colic (or ureteral reflux), particularly in patients with nephrolithiasis. Caution is advised when used on these patients.

Pilocarpine drug interactions

There are 71 drug interactions with pilocarpine

Pilocarpine alcohol/food interactions

There is 1 alcohol/food interaction with pilocarpine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.