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Pilocarpine Dosage

Medically reviewed by Last updated on Jun 6, 2023.

Applies to the following strengths: 5 mg; 7.5 mg; hydrochloride

Usual Adult Dose for Xerostomia

Initial dose: 5 mg orally 3 times a day
Maintenance dose: 15 to 30 mg per day, given in divided doses


Use: Treatment of symptoms of dry mouth from salivary gland hypofunction caused by radiotherapy for head and neck cancer

Usual Adult Dose for Sjogren's Syndrome

5 mg orally 4 times a day

Comment: Efficacy was typically established by the sixth week of use.

Use: Treatment of dry mouth symptoms in patients with Sjogren's syndrome

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh Score 5 to 6): No adjustment recommended.
Moderate liver dysfunction (Child-Pugh Score 6 to 10):

Severe liver dysfunction (Child-Pugh Score 10 to 15): Not recommended.

Patients with known/suspected cholelithiasis or biliary tract disease: Use with caution.



Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.