Physostigmine Disease Interactions
There are 9 disease interactions with physostigmine.
- Bradycardia
- Bronchospasm
- Coronary artery disease
- Parkinsonism
- Asthma
- Cardiovascular disease
- Diabetes
- GI/UT obstruction
- Hyperthyroidism
Cholinesterase inhibitor (applies to physostigmine) bradycardia
Major Potential Hazard, High plausibility. Applicable conditions: Arrhythmias
Due to their pharmacological action, cholinesterase inhibitors can have a vagotonic effect on the sinoatrial and atrioventricular nodes producing bradycardia or heart block. Therapy with cholinesterase inhibitors should be administered cautiously in patients with preexisting bradycardia or underlying cardiac conduction abnormalities. Syncopal episodes have been reported. Atropine may be used to reverse bradycardia produced by cholinesterase inhibitors.
Cholinesterase inhibitor (applies to physostigmine) bronchospasm
Major Potential Hazard, High plausibility. Applicable conditions: Chronic Obstructive Pulmonary Disease, Asthma
Cholinesterase inhibitors inhibit the hydrolysis of acetylcholine. The enhanced effect of acetylcholine produces constriction of the bronchi, increased bronchial secretions, and bronchospasm. Therapy with cholinesterase inhibitors should be administered cautiously in patients with respiratory dysfunction, history of asthma, or obstructive pulmonary disease. Respiratory function should be closely monitored for the occurrence of respiratory adverse reactions. Use of atropine along with discontinuation of the cholinesterase inhibitor may be required for serious respiratory distress.
Cholinesterase inhibitor (applies to physostigmine) coronary artery disease
Major Potential Hazard, High plausibility. Applicable conditions: Ischemic Heart Disease
The use of cholinesterase inhibitors has been associated with a constriction of coronary arteries. Therapy with cholinesterase inhibitors should be administered cautiously in patients with coronary artery disease.
Cholinesterase inhibitor (applies to physostigmine) parkinsonism
Major Potential Hazard, High plausibility.
Cholinesterase inhibitors should be used with caution in patients with parkinsonism. Some of these drugs might be contraindicated in these patients (refer to specific prescribing information). Symptoms of Parkinson's disease may be exacerbated with the increase in cholinergic activity. Caregivers and patients should be advised.
Physostigmine (applies to physostigmine) asthma
Major Potential Hazard, Moderate plausibility.
Physostigmine is a cholinesterase inhibitor that inhibit the hydrolysis of acetylcholine. The enhanced effect of acetylcholine produces constriction of the bronchi, increased bronchial secretions, and bronchospasm. Physostigmine salicylate injection is contraindicated in patients with asthma.
Physostigmine (applies to physostigmine) cardiovascular disease
Major Potential Hazard, Moderate plausibility.
Physostigmine salicylate injection is contraindicated in patients with cardiovascular disease.
Physostigmine (applies to physostigmine) diabetes
Major Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus
Physostigmine salicylate injection is contraindicated in patients with diabetes, and in patients with gangrene.
Physostigmine (applies to physostigmine) GI/UT obstruction
Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction, Urinary Tract Obstruction
Physostigmine is a cholinesterase inhibitor that inhibit the hydrolysis of acetylcholine. Physostigmine salicylate injection is contraindicated in patients with mechanical obstruction of the intestine or urogenital tract or any vagotonic state.
Cholinesterase inhibitor (applies to physostigmine) hyperthyroidism
Moderate Potential Hazard, High plausibility.
Many of the manifestations of hyperthyroidism may be exacerbated by increased levels of acetylcholine produced by cholinesterase inhibitors. Therapy with cholinesterase inhibitors should be administered cautiously to patients with hyperthyroidism. Monitoring of thyroid levels is recommended.
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Physostigmine drug interactions
There are 189 drug interactions with physostigmine.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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