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Physostigmine use while Breastfeeding

Drugs containing Physostigmine: Antilirium, Eserine Sulfate Ophthalmic

Medically reviewed on September 7, 2017

Physostigmine Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of physostigmine during breastfeeding.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[2] and have variable effects on serum prolactin.[3] Physostigmine increases serum prolactin in humans.[4][5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


1. Clarke G, Fall CH, Lincoln DW, Merrick LP. Effects of cholinoceptor antagonists on the suckling-induced and experimentally evoked release of oxytocin. Br J Pharmacol. 1978;63:519-27. PMID: 566601

2. Muller EE, Locatelli V, Cella S et al. Prolactin-lowering and -releasing drugs: mechanisms of action and therapeutic applications. Drugs. 1983;25:399-432. PMID: 6133737

3. Risch SC, Janowsky DS, Siever LJ al. Correlated cholinomimetic-stimulated beta-endorphin and prolactin release in humans. Peptides. 1982;3:319-22. PMID: 6289276

4. Risch SC, Janowsky DS, Siever LJ et al. Cholinomimetic-induced co-release of prolactin and beta-endorphin in man. Psychopharmacol Bull. 1982;18:21-5. PMID: 6296908

Physostigmine Identification

Substance Name


CAS Registry Number


Drug Class

Cholinesterase Inhibitors


Administrative Information

LactMed Record Number



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Further information

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