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Physostigmine Side Effects

For the Consumer

Applies to physostigmine: parenteral injection

Side effects include:

Nausea, vomiting, epigastric pain, miosis, salivation, sweating, lacrimation, dyspnea, bronchospasm.

For Healthcare Professionals

Applies to physostigmine: injectable solution


Frequency not reported: Nausea, vomiting, hypersalivation[Ref]

Nausea, vomiting, and salivation can be offset by a reduction in dosage.[Ref]


Frequency not reported: Bradycardia[Ref]

Bradycardia may occur if intravenous administration is too rapid.[Ref]

Nervous system

Convulsions may occur if intravenous administration is too rapid.[Ref]

Frequency not reported: Convulsions[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Physostigmine Salicylate (physostigmine)." Taylor Pharmaceuticals, Buffalo Grove, IL.

Some side effects of physostigmine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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