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Physostigmine Side Effects

Medically reviewed by Last updated on Aug 15, 2023.

Applies to physostigmine: parenteral injection.

Side effects include:

Nausea, vomiting, epigastric pain, miosis, salivation, sweating, lacrimation, dyspnea, bronchospasm.

For Healthcare Professionals

Applies to physostigmine: injectable solution.


Frequency not reported: Nausea, vomiting, hypersalivation[Ref]

Nausea, vomiting, and salivation can be offset by a reduction in dosage.[Ref]


Frequency not reported: Bradycardia[Ref]

Bradycardia may occur if intravenous administration is too rapid.[Ref]

Nervous system

Convulsions may occur if intravenous administration is too rapid.[Ref]

Frequency not reported: Convulsions[Ref]


1. Cerner Multum, Inc. Australian Product Information.

2. Product Information. Physostigmine Salicylate (physostigmine). Taylor Pharmaceuticals. 2016.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.