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Definity Disease Interactions

There are 2 disease interactions with Definity (perflutren).


Perflutren (applies to Definity) cardiopulmonary reactions

Major Potential Hazard, Moderate plausibility. Applicable conditions: Myocardial Infarction, Congestive Heart Failure, Ventricular Arrhythmia

Serious cardiopulmonary reactions including fatalities have uncommonly occurred during or shortly following perflutren- containing microsphere administration, typically within 30 minutes of administration. The risk may be increased among patients with unstable cardiopulmonary conditions such as acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, or serious ventricular arrhythmias. Always have cardiopulmonary resuscitation personnel and equipment readily available prior to perflutren administration and monitor all patients for acute reactions.


  1. (2015) "Product Information. Definity (perflutren)." Lantheus Medical Imaging Inc

Perflutren (applies to Definity) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The pharmacokinetics of activated perflutren has not been studied in subjects with hepatic disease. Caution is advised if used in these patients.


  1. (2015) "Product Information. Definity (perflutren)." Lantheus Medical Imaging Inc

Definity drug interactions

There are 239 drug interactions with Definity (perflutren).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.