Definity RT Disease Interactions
There are 2 disease interactions with Definity RT (perflutren).
Perflutren (applies to Definity RT) cardiopulmonary reactions
Major Potential Hazard, Moderate plausibility. Applicable conditions: Myocardial Infarction, Congestive Heart Failure, Ventricular Arrhythmia
Serious cardiopulmonary reactions including fatalities have uncommonly occurred during or shortly following perflutren- containing microsphere administration, typically within 30 minutes of administration. The risk may be increased among patients with unstable cardiopulmonary conditions such as acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, or serious ventricular arrhythmias. Always have cardiopulmonary resuscitation personnel and equipment readily available prior to perflutren administration and monitor all patients for acute reactions.
Perflutren (applies to Definity RT) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The pharmacokinetics of activated perflutren has not been studied in subjects with hepatic disease. Caution is advised if used in these patients.
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Definity RT drug interactions
There are 244 drug interactions with Definity RT (perflutren).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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