Palovarotene Disease Interactions
There are 3 disease interactions with palovarotene.
Palovarotene (applies to palovarotene) liver disease
Moderate Potential Hazard, Moderate plausibility.
The use of palovarotene in patients with moderate or severe liver dysfunction (Child-Pugh B and C) is not recommended. No dose adjustment of palovarotene is recommended for patients with mild liver dysfunction (Child-Pugh A). The effect of moderate or severe liver dysfunction on palovarotene pharmacokinetics has not been evaluated.
References (1)
- (2025) "Product Information. Sohonos (palovarotene)." Ipsen Biopharmaceuticals, Inc, SUPPL-2
Palovarotene (applies to palovarotene) psychiatric illness
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Depression, Psychosis, History - Psychiatric Disorder
New or worsening psychiatric events have been reported with the use of palovarotene. Patients with a history of psychiatric illness may be more susceptible to the adverse effects including depression, anxiety, mood alterations, and suicidal thoughts and behaviors. Patients should be monitored for the development of new or worsening psychiatric symptoms during treatment with palovarotene.
References (1)
- (2025) "Product Information. Sohonos (palovarotene)." Ipsen Biopharmaceuticals, Inc, SUPPL-2
Palovarotene (applies to palovarotene) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The use of palovarotene in patients with severe renal dysfunction (CrCl 15 to 29 mL/min) is not recommended. No dose adjustment of palovarotene is recommended for patients with mild or moderate renal dysfunction (CrCl 30 to 89 mL/min). The effect of renal dysfunction on palovarotene pharmacokinetics has not been evaluated.
References (1)
- (2025) "Product Information. Sohonos (palovarotene)." Ipsen Biopharmaceuticals, Inc, SUPPL-2
Switch to consumer interaction data
Palovarotene drug interactions
There are 212 drug interactions with palovarotene.
Palovarotene alcohol/food interactions
There is 1 alcohol/food interaction with palovarotene.
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More about palovarotene
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- Dosage information
- During pregnancy
- Drug class: miscellaneous uncategorized agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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