Nedosiran Disease Interactions
There are 2 disease interactions with nedosiran.
Nedosiran (applies to nedosiran) hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Nedosiran has not been studied in patients with moderate or severe liver disease (total bilirubin greater than 1.5 upper limit of normal with any aspartate aminotransferase).
Nedosiran (applies to nedosiran) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Nedosiran has not been studied in patients with severe renal dysfunction (eGFR less than 30 mL/min/1.73m2).
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- During pregnancy
- Drug class: miscellaneous metabolic agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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