Rivfloza Disease Interactions
There are 2 disease interactions with Rivfloza (nedosiran).
Moderate
Nedosiran (applies to Rivfloza) hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Nedosiran has not been studied in patients with moderate or severe liver disease (total bilirubin greater than 1.5 upper limit of normal with any aspartate aminotransferase).
Moderate
Nedosiran (applies to Rivfloza) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Nedosiran has not been studied in patients with severe renal dysfunction (eGFR less than 30 mL/min/1.73m2).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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