Rivfloza Dosage

Generic name: NEDOSIRAN SODIUM 160mg in 1mL
Dosage form: injection, solution
Drug class: Miscellaneous metabolic agents

Medically reviewed by Drugs.com. Last updated on Mar 3, 2025.

Recommended Dosage

RIVFLOZA is administered subcutaneously once monthly at the recommended doses shown in Table 1.

Dosing is based on actual body weight.

Table 1: RIVFLOZA Dose Regimen in Adults and Pediatric Patients (2 years of age and older)

	Body weight
	Less than 39 kg	39 kg to less than 50 kg	50 kg and above
Age 2 to less than 12 years	3.3 mg/kg	128 mg	160 mg
Age 12 years and older	128 mg		160 mg

Missed Dose

If a planned dose is missed, administer RIVFLOZA as soon as possible. If the planned dose is missed by more than 7 days, administer RIVFLOZA as soon as possible and resume monthly dosing from the most recently administered dose.

Administration Instructions

Pre-filled syringe: A healthcare provider, caregiver, or patient 12 years of age and older may inject RIVFLOZA using the pre-filled syringe. In pediatric patients 2 to less than 12 years of age who weigh ≥39 kg, a healthcare provider or caregiver may inject RIVFLOZA using the pre-filled syringe.

Vials: RIVFLOZA vials are intended for use under the guidance and supervision of a healthcare provider. Adult patients or caregivers may administer RIVFLOZA after proper training in preparing RIVFLOZA vials for administration, if a healthcare provider determines that it is appropriate, and with medical follow-up as necessary.

Administer RIVFLOZA by subcutaneous injection to the abdomen (at least 2 inches from the navel) or the upper thigh. Do not inject into a vein or into scarred or bruised skin.

Inspect visually for particulate matter and discoloration prior to injection. RIVFLOZA should be colorless-to-yellow and particle free. If the solution is cloudy or contains particulate matter, do not use.

Instructions for delivering the dosage are provided in the Instructions for Use leaflets enclosed with the RIVFLOZA Pre-filled Syringe and single-dose vial.

Discard the unused portion of the drug.