Skip to Content

Nalmefene Disease Interactions

There is 1 disease interaction with nalmefene:

Moderate

Opiate antagonists (applies to nalmefene) hepatic/renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Opiate antagonists are metabolized by the liver (naltrexone to an active metabolite) and eliminated by the kidney. Hepatic and renal impairment may reduce the metabolism and clearance of opiate antagonists. Dosage adjustment for single dose administration is not necessary, however, repeated doses in patients with hepatic and/or renal dysfunction may require adjustment.

References

  1. "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.
  2. "Product Information. Revex (nalmefene)." Ohmeda Pharmaceutical Products Division, Liberty Corner, NJ.

Nalmefene drug interactions

There are 7 drug interactions with nalmefene

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.