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Metyrosine Disease Interactions

There are 3 disease interactions with metyrosine:

Moderate

Metyrosine (applies to metyrosine) extrapyramidal symptoms

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Parkinsonism

Extrapyramidal symptoms (EPS) have occurred in approximately 10% of patients receiving metyrosine. EPS include drooling, speech difficulty, and tremor. Trismus and parkinsonian syndrome have been reported. Therapy with metyrosine should be administered cautiously in patients with or predisposition to EPS or Parkinson's disease. Dosage reduction or discontinuation of metyrosine may be necessary.

References

  1. "Product Information. Demser (metyrosine)." Merck & Co, Inc, West Point, PA.
Moderate

Metyrosine (applies to metyrosine) psychoses and emotional disturbances

Moderate Potential Hazard, Low plausibility. Applicable conditions: Psychosis

Anxiety, excitability, and psychic disturbances such as hallucinations, disorientation/confusion, emotional instability, and depression have occurred in patients receiving metyrosine. Therapy with metyrosine should be administered cautiously in patients with psychiatric and/or emotional disorders. Dosage reduction may be appropriate. Clinical monitoring of emotional and psychiatric status is recommended.

References

  1. "Product Information. Demser (metyrosine)." Merck & Co, Inc, West Point, PA.
Moderate

Metyrosine (applies to metyrosine) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Metyrosine is primarily eliminated by the kidney. The serum concentration of metyrosine may be increased in patients with renal impairment. Therapy with metyrosine should be administered cautiously in patient with compromised renal function. Clinical monitoring of renal function is recommended.

References

  1. "Product Information. Demser (metyrosine)." Merck & Co, Inc, West Point, PA.

Metyrosine drug interactions

There are 235 drug interactions with metyrosine

Metyrosine alcohol/food interactions

There is 1 alcohol/food interaction with metyrosine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.