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Methoxsalen topical Disease Interactions

There are 4 disease interactions with methoxsalen topical:

Major

Methoxsalen (applies to methoxsalen topical) photosensitivity states

Major Potential Hazard, High plausibility. Applicable conditions: Porphyria, Lupus Erythematosus

The use of methoxsalen with ultraviolet radiation is contraindicated in patients with a history of photosensitive disease states. Methoxsalen is a potent photosensitizer that can induce severe burns and marked hyperpigmentation and aging of skin in susceptible patients or when used improperly. Diseases associated with photosensitivity include lupus erythematosus, porphyria cutanea tarda, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum, and albinism.

References

  1. "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA.
  2. "Product Information. Oxsoralen Lotion (methoxsalen topical)." ICN Pharmaceuticals, Costa Mesa, CA.
Major

Methoxsalen (applies to methoxsalen topical) skin cancer

Major Potential Hazard, High plausibility. Applicable conditions: History - Skin Cancer

The use of methoxsalen (a psoralen) with ultraviolet radiation (UVA) is contraindicated in patients with melanoma, invasive squamous cell carcinomas, or a history of melanoma. PUVA (psoralen and UVA photochemotherapy) may be associated with increased risks of squamous cell carcinoma, basal cell carcinoma and melanoma. Methoxsalen markedly enhances skin reactivity to UVA, and exposure to sunlight and/or UVA can cause premature aging of the skin and skin cancer. If necessary, patients with a current or past history of multiple basal cell carcinomas or other nonmelanoma skin cancers may be treated with PUVA but should be carefully monitored. The usual restrictions concerning sun exposure before and after treatment as well as prescribed dosage must be followed closely.

References

  1. "Product Information. Oxsoralen Lotion (methoxsalen topical)." ICN Pharmaceuticals, Costa Mesa, CA.
  2. "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA.
Moderate

Methoxsalen (applies to methoxsalen topical) previous x-ray therapy

Moderate Potential Hazard, High plausibility. Applicable conditions: History - Radiation Therapy

PUVA (psoralen and UVA photochemotherapy) may be associated with increased risks of squamous cell carcinoma, basal cell carcinoma and melanoma. Methoxsalen, a psoralen, markedly enhances skin reactivity to UVA radiation, and exposure to sunlight and/or UVA can cause premature aging of the skin and skin cancer. The total lifetime dose of UVA that can be safely administered has not been established. Therefore, PUVA should be given cautiously in patients with a history of x-ray or grenz ray therapy. Close monitoring for signs of carcinoma is recommended. The usual restrictions concerning sun exposure before and after treatment as well as prescribed dosage must be followed closely.

References

  1. "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA.
  2. "Product Information. Oxsoralen Lotion (methoxsalen topical)." ICN Pharmaceuticals, Costa Mesa, CA.
Moderate

Methoxsalen (applies to methoxsalen topical) sunburn

Moderate Potential Hazard, High plausibility.

Patients presenting with a sunburn should not be treated with methoxsalen (a psoralen) and ultraviolet radiation (UVA), since it may be difficult to evaluate the response of these patients to therapy. The mild, transient erythema normally seen 24 to 48 hours after PUVA (psoralen and UVA photochemotherapy) indicates a therapeutic interaction occurring between the psoralen and UVA but may be masked by a sunburn. Patients generally should avoid sunbathing for at least 24 hours prior to methoxsalen administration and UVA exposure. The usual restrictions concerning sun exposure after treatment and the prescribed dosage should also be followed closely to avoid severe burns and other phototoxic reactions.

References

  1. "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA.
  2. "Product Information. Oxsoralen Lotion (methoxsalen topical)." ICN Pharmaceuticals, Costa Mesa, CA.

Methoxsalen topical drug interactions

There are 6 drug interactions with methoxsalen topical

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.